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Comment
. 2012 Nov 13;22(5):565-6.
doi: 10.1016/j.ccr.2012.10.014.

PGAMgnam style: a glycolytic switch controls biosynthesis

Barbara Chaneton  1 , Eyal Gottlieb
Affiliations
Free article
Comment

PGAMgnam style: a glycolytic switch controls biosynthesis

Barbara Chaneton et al. Cancer Cell. .
Free article

Abstract

Therapeutic strategies that target glycolysis and biosynthetic pathways in cancer cells are currently the main focus of research in the field of cancer metabolism. In this issue of Cancer Cell, Hitosugi and colleagues show that targeting PGAM1 could be a way of "killing two birds with one stone".

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  • Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
    Hitosugi T, Zhou L, Elf S, Fan J, Kang HB, Seo JH, Shan C, Dai Q, Zhang L, Xie J, Gu TL, Jin P, Alečković M, LeRoy G, Kang Y, Sudderth JA, DeBerardinis RJ, Luan CH, Chen GZ, Muller S, Shin DM, Owonikoko TK, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Ye K, Boggon TJ, Kang S, He C, Chen J. Hitosugi T, et al. Cancer Cell. 2012 Nov 13;22(5):585-600. doi: 10.1016/j.ccr.2012.09.020. Cancer Cell. 2012. PMID: 23153533 Free PMC article.

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