Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Dec;10(12):807-13.
doi: 10.1038/nrmicro2893.

Structural vaccinology starts to deliver

Philip R Dormitzer  1 , Guido Grandi, Rino Rappuoli
Affiliations
Review

Structural vaccinology starts to deliver

Philip R Dormitzer et al. Nat Rev Microbiol. 2012 Dec.

Abstract

Following the impact of the genomics revolution on vaccine research and the development of reverse vaccinology, it was predicted that another new approach, structure-based antigen design, would become a driving force for vaccine innovation. Now, 5 years on, there are several examples of how structure-based design, or structural vaccinology, can deliver new vaccine antigens that were not possible before. Here, we discuss some of these examples and the contribution of structural vaccinology to our understanding of the protective epitopes of important bacterial and viral pathogens.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10278-83 - PubMed
    1. Infect Immun. 2011 Sep;79(9):3751-9 - PubMed
    1. Nature. 2006 Jan 5;439(7072):38-44 - PubMed
    1. Trends Biotechnol. 2008 Dec;26(12):659-67 - PubMed
    1. Am J Epidemiol. 1969 Apr;89(4):422-34 - PubMed

Publication types

LinkOut - more resources