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Comment
. 2012 Nov 15;3(7):594-6.
doi: 10.4161/viru.22496. Epub 2012 Nov 15.

Turning up Francisella pathogenesis: the LPS thermostat

Daniel A Powell  1 , Yanyan Li, Robert K Ernst
Affiliations
Comment

Turning up Francisella pathogenesis: the LPS thermostat

Daniel A Powell et al. Virulence. .
No abstract available

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Figures

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Figure 1. Overview of lpxD control of pathogenesis. Francisella has a unique ability to adapt upon entering various environmental niches. Of particular interest is the activity of the acyltransferases LpxD1 and LpxD2. Upon entry of warm temperatures Francisella upregulates lpxD1 and this causes a larger lipid A structure, leading to decreased permeability as well as decreased sensitivity to killing by CAMPs. Conversely at cooler temperatures lpxD2 is upregulated, generating a smaller lipid A giving rise to increased permeability and sensitivity to CAMPs. Mutants of lpxD1 locked in the cooler state become avirulent while mutants of lpxD2 locked in the warm state remain virulent.
See this image and copyright information in PMC

Comment on

  • LPS remodeling is an evolved survival strategy for bacteria.
    Li Y, Powell DA, Shaffer SA, Rasko DA, Pelletier MR, Leszyk JD, Scott AJ, Masoudi A, Goodlett DR, Wang X, Raetz CR, Ernst RK. Li Y, et al. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8716-21. doi: 10.1073/pnas.1202908109. Epub 2012 May 14. Proc Natl Acad Sci U S A. 2012. PMID: 22586119 Free PMC article.

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