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Comment
. 2012 Nov 15;26(22):2468-70.
doi: 10.1101/gad.207126.112.

Zebrafish genetics gets the Scube on Hedgehog secretion

Philip W Ingham  1
Affiliations
Comment

Zebrafish genetics gets the Scube on Hedgehog secretion

Philip W Ingham. Genes Dev. .

Abstract

Inspired by a zebrafish mutation, two recent studies by Creanga and colleagues (pp. 1312-1325) and Tukachinsky and colleagues have shed new light on the way in which lipidated Hedgehog proteins are secreted and released from expressing cells, suggesting a model for the sequential action of the Disp and Scube2 proteins in this process.

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References

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