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Comparative Study
. 1990 Mar 16;247(4948):1306-10.
doi: 10.1126/science.2315699.

Deciphering the message in protein sequences: tolerance to amino acid substitutions

J U Bowie  1 , J F Reidhaar-Olson, W A Lim, R T Sauer
Affiliations
Comparative Study

Deciphering the message in protein sequences: tolerance to amino acid substitutions

J U Bowie et al. Science. .

Abstract

An amino acid sequence encodes a message that determines the shape and function of a protein. This message is highly degenerate in that many different sequences can code for proteins with essentially the same structure and activity. Comparison of different sequences with similar messages can reveal key features of the code and improve understanding of how a protein folds and how it performs its function.

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