Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2013 Mar;115(3):e28-33.
doi: 10.1016/j.oooo.2012.07.481. Epub 2012 Nov 13.

MALT lymphoma in labial salivary gland biopsy from Sjögren syndrome: importance of follow-up in early detection

A Keszler  1 , L I Adler, M S Gandolfo, P A Masquijo Bisio, A C Smith, C F Vollenweider, A M Heidenreich, G de Stefano, M V Kambo, D P Cox, M Narbaitz, H E Lanfranchi
Affiliations
Case Reports

MALT lymphoma in labial salivary gland biopsy from Sjögren syndrome: importance of follow-up in early detection

A Keszler et al. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Mar.

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphomas are known to occur in Sjögren syndrome (SS) patients, but reported cases in labial salivary glands (LSG) are rare. We report a case of 60-year-old female patient with SS who developed MALT lymphoma in the labial salivary glands during a 2-year time interval when she was participating in the Sjögren's International Clinical Collaborative Alliance, an ongoing longitudinal multisite observational study funded by the National Institutes of Health of the United States. At follow-up exam, LSG biopsy showed atypical diffuse infiltration by mononuclear cells of variable size and atypical nuclei affecting the whole specimen with destruction of glandular architecture, leading to a diagnosis of B-cell MALT lymphoma. Computerized tomography and bone marrow biopsy failed to show additional evidence of disease. Clinical, serologic, ocular, histologic and immunohistochemical findings are presented. A "watch and wait" policy was adopted with regular examinations.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Histomorphology and immunohistochemistry of MALT lymphoma in minor salivary gland follow up biopsy; A: Hematoxylin-eosin (Original magnification ×40), B: CD20 (positive) in most lymphocytes exhibiting a diffuse pattern, C: CD3 (negative) identifies scattered T-cells of the lymphocytic infiltrate, D: Kappa light chain restriction, E: Bcl-2 positive staining, F: Ki-67 positive expression <5% of neoplastic cells. (Original magnification ×100).
See this image and copyright information in PMC

References

    1. Daniels T, Fox P. Salivary and oral components of Sjögren’s syndrome. Rheum Dis Clin North Am. 1992;18:571–89. - PubMed
    1. Hernández YL, Daniels TE. Oral candidiasis in Sjögren’s syndrome: prevalence, clinical correlations, and treatment. Oral Surg Oral Med Oral Pathol. 1989;68:324–9. - PubMed
    1. Ferraccioli GF, Sorrentino D, De Vita S, Casatta L, Labombarda A, Avellini C, Dolcetti R, Di Luca D, Beltrami CA, Boiocchi M, Bartoli E. B cell clonality in gastric lymphoid tissues of patients with Sjögren’s syndrome. Ann Rheum Dis. 1996;55:311–6. - PMC - PubMed
    1. Aragona P. Presence of antibodies against Helicobacter pylori and its heat-shock protein 60 in the serum of patients with Sjögren’s syndrome. J Rheumatol. 1999;26:1306–11. - PubMed
    1. Brown LM. Helicobacter pylori: epidemiology and routes of transmission. Epidemiol Rev. 2000;22:283–97. - PubMed

Publication types