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. 2012 Dec;43(6):611-20.
doi: 10.1016/j.amepre.2012.08.014.

Inflammation and early-life abuse in women

Elizabeth R Bertone-Johnson  1 , Brian W Whitcomb, Stacey A Missmer, Elizabeth W Karlson, Janet W Rich-Edwards
Affiliations

Inflammation and early-life abuse in women

Elizabeth R Bertone-Johnson et al. Am J Prev Med. 2012 Dec.

Abstract

Background: Abuse in childhood and adolescence may affect risks of diabetes and cardiovascular disease later in life. Although mechanisms underlying these relationships are unclear, chronic stress may lead to dysregulation of immune function and chronic inflammation.

Purpose: To evaluate associations between early-life physical and sexual abuse and blood levels of inflammatory markers in adulthood among 702 members of the Nurses' Health Study II.

Methods: Abuse in childhood (before age 11 years) and adolescence (ages 11-17 years) was self-reported in 2001. Plasma samples collected in 1996-1999 were assayed for C-reactive protein (CRP); interleukin (IL)-6; and the soluble fraction of tumor necrosis factor alpha receptor 2 in 2001, 2009, and 2010.

Results: Mean age at blood collection was 43.9 years. Moderate or severe physical abuse was reported by 35.3% of participants; 22.7% reported unwanted sexual touching and 9.8% reported forced sex. Plasma levels of CRP and IL-6 were higher in women reporting sexual abuse in adolescence compared to those reporting no abuse (p=0.04 and 0.03, respectively) in analyses adjusted for confounders including age and childhood adiposity. Inflammatory marker levels similarly were elevated in women reporting sexual abuse during childhood, but results were not significant. Relationships largely persisted after further adjustment for potential mediators such as adult BMI and smoking. Physical abuse during childhood and/or adolescence was not consistently associated with inflammatory marker levels.

Conclusions: Chronic inflammation may be one mechanism through which sexual abuse may affect future risk of physical and psychological disorders.

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Conflict of interest statement

No financial disclosures were reported by the authors of this paper.

References

    1. Edwards VJ, Holden GW, Felitti VJ, Anda RF. Relationship between multiple forms of childhood maltreatment and adult mental health in community respondents: Results from the Adverse Childhood Experiences study. Am J Psychiatry. 2003;160(8):1453–1460. - PubMed
    1. Felitti VJ, Anda RF, Nordenberg D, et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. Am J Prev Med. 1998;14(4):245–258. - PubMed
    1. Rich-Edwards JW, Spiegelman D, Lividoti Hibert EN, et al. Abuse in childhood and adolescence as a predictor of type 2 diabetes in adult women. Am J Prev Med. 2010;39(6):529–536. - PMC - PubMed
    1. Boynton-Jarrett R, Rich-Edwards JW, Jun HJ, Hibert EN, Wright RJ. Abuse in childhood and risk of uterine leiomyoma: The role of emotional support in biologic resilience. Epidemiology. 2011;22(1):6–14. - PMC - PubMed
    1. Danese A, Pariante CM, Caspi A, Taylor A, Poulton R. Childhood maltreatment predicts adult inflammation in a life-course study. Proc Natl Acad Sci USA. 2007;104(4):1319–1324. - PMC - PubMed

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