Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Feb;208(2):127.e1-8.
doi: 10.1016/j.ajog.2012.11.007. Epub 2012 Nov 15.

Obstetric complications among US women with asthma

Pauline Mendola  1 , S Katherine Laughon, Tuija I Männistö, Kira Leishear, Uma M Reddy, Zhen Chen, Jun Zhang
Affiliations

Obstetric complications among US women with asthma

Pauline Mendola et al. Am J Obstet Gynecol. 2013 Feb.

Abstract

Objective: We sought to characterize complications of pregnancy, labor, and delivery associated with maternal asthma in a contemporary US cohort.

Study design: We studied a retrospective cohort based on electronic medical record data from 223,512 singleton deliveries from 12 clinical centers across the United States from 2002 through 2008.

Results: Women with asthma had higher odds of preeclampsia (adjusted odds ratio [aOR], 1.14; 95% confidence interval [CI], 1.06-1.22), superimposed preeclampsia (aOR, 1.34; 95% CI, 1.15-1.56), gestational diabetes (aOR, 1.11; 95% CI, 1.03-1.19), placental abruption (aOR, 1.22; 95% CI, 1.09-1.36), and placenta previa (aOR, 1.30; 95% CI, 1.08-1.56). Asthmatic women had a higher odds of preterm birth overall (aOR, 1.17; 95% CI, 1.12-1.23) and of medically indicated preterm delivery (aOR, 1.14; 95% CI, 1.01-1.29). Asthmatics were less likely to have spontaneous labor (aOR, 0.87; 95% CI, 0.84-0.90) and vaginal delivery (aOR, 0.84; 95% CI, 0.80-0.87). Risks were higher for breech presentation (aOR, 1.13; 95% CI, 1.05-1.22), hemorrhage (aOR, 1.09; 95% CI, 1.03-1.16), pulmonary embolism (aOR, 1.71; 95% CI, 1.05-2.79), and maternal intensive care unit admission (aOR, 1.34; 95% CI, 1.04-1.72).

Conclusion: Maternal asthma increased risk for nearly all outcomes studied in a general obstetric population.

PubMed Disclaimer

References

    1. Kwon HL, Triche EW, Belanger K, Bracken MB. The epidemiology of asthma during pregnancy: prevalence, diagnosis, and symptoms. Immunol.Allergy Clin.North Am. 2006;26:29–62. - PubMed
    1. CDC. National Center for Health Statistics . National Center for Health Statistics. Health Data Interactive. 7-24-0012. Ref Type: Electronic Citation.
    1. CDC . Health United States, 2011: With Special Feature on Socioeconomic Status and Health. CDC; National Center for Health Statistics; Hyattsville, MD: 2012. - PubMed
    1. Berg CJ, Mackay AP, Qin C, Callaghan WM. Overview of maternal morbidity during hospitalization for labor and delivery in the United States: 1993–1997 and 2001–2005. Obstet.Gynecol. 2009;113:1075–81. - PubMed
    1. Murphy VE, Namazy JA, Powell H, Schatz M, Chambers C, Attia J, et al. A meta-analysis of adverse perinatal outcomes in women with asthma. BJOG. 2011;118:1314–23. - PubMed

Publication types

MeSH terms