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Review
. 2012:63:83-95.
doi: 10.1007/978-94-007-4765-4_5.

Regulation of post-Golgi traffic of G protein-coupled receptors

Guangyu Wu  1
Affiliations
Review

Regulation of post-Golgi traffic of G protein-coupled receptors

Guangyu Wu. Subcell Biochem. 2012.

Abstract

Anterograde trafficking of newly synthesized G protein-coupled -receptors (GPCRs) from the endoplasmic reticulum to the cell surface represents a crucial checkpoint in controlling the amount of the functional receptors at the cell surface and the strength of signaling initiated by the receptors. In contrast to the extensively studied, well-understood endocytic and recycling pathways, the molecular mechanisms underlying the cell-surface targeting of the receptors remain poorly defined. In this chapter, I will discuss current advances in understanding post-Golgi transport of GPCRs by focusing on specific motifs or sequences that may function as sorting signals regulating export from the Golgi and subsequent transport to the plasma membrane of GPCRs.

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Figures

Fig. 5.1
Fig. 5.1
The formation of clathrin- and GGA-coated vesicles on the TGN membrane and the possible function of the interaction of GPCRs, via their C-termini, with ARF1 in facilitating receptor recruitment onto the vesicles
Fig. 5.2
Fig. 5.2
The conserved YS motif in the N-termini (NT) of three α2-AR subtypes
See this image and copyright information in PMC

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