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. 2012 Dec 21;51(52):13173-7.
doi: 10.1002/anie.201206658. Epub 2012 Nov 19.

Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen

Katharina Graupner  1 , Kirstin Scherlach, Tom Bretschneider, Gerald Lackner, Martin Roth, Harald Gross, Christian Hertweck
Affiliations

Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen

Katharina Graupner et al. Angew Chem Int Ed Engl. .

Abstract

Caught in the act: imaging mass spectrometry of a button mushroom infected with the soft rot pathogen Janthinobacterium agaricidamnosum in conjunction with genome mining revealed jagaricin as a highly antifungal virulence factor that is not produced under standard cultivation conditions. The structure of jagaricin was rigorously elucidated by a combination of physicochemical analyses, chemical derivatization, and bioinformatics.

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