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. 2013 Jan;41(Database issue):D344-7.
doi: 10.1093/nar/gks1067. Epub 2012 Nov 17.

New and continuing developments at PROSITE

Christian J A Sigrist  1 , Edouard de Castro, Lorenzo Cerutti, Béatrice A Cuche, Nicolas Hulo, Alan Bridge, Lydie Bougueleret, Ioannis Xenarios
Affiliations

New and continuing developments at PROSITE

Christian J A Sigrist et al. Nucleic Acids Res. 2013 Jan.

Abstract

PROSITE (http://prosite.expasy.org/) consists of documentation entries describing protein domains, families and functional sites, as well as associated patterns and profiles to identify them. It is complemented by ProRule a collection of rules, which increases the discriminatory power of these profiles and patterns by providing additional information about functionally and/or structurally critical amino acids. PROSITE signatures, together with ProRule, are used for the annotation of domains and features of UniProtKB/Swiss-Prot entries. Here, we describe recent developments that allow users to perform whole-proteome annotation as well as a number of filtering options that can be combined to perform powerful targeted searches for biological discovery. The latest version of PROSITE (release 20.85, of 30 August 2012) contains 1308 patterns, 1039 profiles and 1041 ProRules.

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Figures

Figure 1.
Figure 1.
The use of logical operators in ScanProsite. The PROSITE profiles used are PS50122 (CHEB), PS50123 (CHER) and PS50110 (RESPONSE_REGULATORY). The matched architectures correspond to the following UniProtKB/Swiss-Prot entries: Q02998 (YH19_RHOCA), A1SMR4 (CHEB_NOCSJ), P31758 (FRZG_MYXXA), P31759 (FRZF_MYXXA) and A1VZQ6 (CHER_CAMJJ). Single-asterisk symbol denotes that ‘not’ has to be used with another operator (‘and’ or ‘or’). Double-asterisk symbol denotes that parentheses have to be preceded and followed by a space.
See this image and copyright information in PMC

References

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