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. 2012 May;5(2):166-9.
doi: 10.4103/0974-1208.101012.

Effects of metformin use in pregnant patients with polycystic ovary syndrome

Pratap Kumar  1 , Kashif Khan
Affiliations

Effects of metformin use in pregnant patients with polycystic ovary syndrome

Pratap Kumar et al. J Hum Reprod Sci. 2012 May.

Abstract

Use of metformin throughout pregnancy in women with polycystic ovary syndrome (PCOS) has shown to reduce the rates of early pregnancy loss, preterm labor, and prevention of fetal growth restriction. Metformin has been shown to have encouraging effects on several metabolic aspects of polycystic ovarian syndrome, such as insulin sensitivity, plasma glucose concentration and lipid profile and since women with PCOS are more likely than healthy women to suffer from pregnancy-related problems like early pregnancy loss, gestational diabetes mellitus and hypertensive states in pregnancy, the use of metformin therapy in these patients throughout pregnancy may have beneficial effects on early pregnancy loss and development of gestational diabetes.

Keywords: Metformin; PCOS; pregnancy.

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Conflict of interest statement

Conflict of Interest: None declared.

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