doi: 10.4161/onci.21455.
The early antitumor immune response is necessary for tumor growth: Re-visiting Prehn's hypothesis in the human melanoma system
Affiliations
- PMID: 23162761
- PMCID: PMC3489749
- DOI: 10.4161/onci.21455
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The early antitumor immune response is necessary for tumor growth: Re-visiting Prehn's hypothesis in the human melanoma system
Oncoimmunology.
.
Abstract
Early events responsible of tumor growth in patients with a normal immune system are poorly understood. Here, we discuss, in the context of human melanoma, the Prehn hypothesis according to which a weak antitumor immune response may be required for tumor growth before weakly or non-immunogenic tumor cell subpopulations are selected by the immune system.
Figures
Figure 1. The UVB-induced transformation of melanocytes causes the expression of mutated tumor-associated antigens (mTAA), hence triggering an inflammatory, immune and/or pro-angiogenic response that favors early tumor growth.
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References
-
- Burnet FM. The concept of immunological surveillance. Prog Exp Tumor Res. 1970;13:1–27. - PubMed
-
- Parmiani G, Sensi ML, Castelli C, Rivoltini L, Anichini A. T-cell response to unique and shared antigens and vaccination of cancer patients. Cancer Immun. 2002;2:6. - PubMed
-
- Rivoltini L, Canese P, Huber V, Iero M, Pilla L, Valenti R, et al. Escape strategies and reasons for failure in the interaction between tumour cells and the immune system: how can we tilt the balance towards immune-mediated cancer control? Expert Opin Biol Ther. 2005;5:463–76. doi: 10.1517/14712598.5.4.463. - DOI - PubMed
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