Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Apr;46(4):754-61.

The parental origin of the extra X chromosome in 47,XXX females

K M May  1 , P A Jacobs, M Lee, S Ratcliffe, A Robinson, J Nielsen, T J Hassold
Affiliations

The parental origin of the extra X chromosome in 47,XXX females

K M May et al. Am J Hum Genet. 1990 Apr.

Abstract

We used X-linked DNA polymorphisms to study the parental origin of X chromosome nondisjunction in 28 47,XXX live-born females. Errors in oogenesis accounted for 26 of the cases, with the majority of these being attributable to an error at meiosis I. We observed an association between advanced parental age and meiosis I nondisjunction--but not meiosis II nondisjunction--in the maternally derived cases. In studies of recombination we found little evidence for an association between pairing failure and X chromosome nondisjunction, but our results suggest that increased recombination near the centromere may play a role in the etiology of the 47,XXX condition.

PubMed Disclaimer

References

    1. J Mol Biol. 1977 Jun 15;113(1):237-51 - PubMed
    1. Genomics. 1989 Jul;5(1):144-8 - PubMed
    1. Cytogenet Cell Genet. 1989;51(1-4):622-947 - PubMed
    1. J Med Genet. 1971 Dec;8(4):417-26 - PubMed
    1. Am J Med Genet. 1983 Sep;16(1):111-6 - PubMed

Publication types

LinkOut - more resources