Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Oct;21(5):395-400.
doi: 10.1097/PAI.0b013e318277d9de.

The correlations of LMX1A and osteopontin expression to the clinicopathologic stages in pancreatic adenocarcinoma

Wen-Chiuan Tsai  1 , Chih-Kung Lin, Ya-Sung Yang, De-Chuan Chan, Hong-Wei Gao, Fei-Ni Chang, Jong-Shiaw Jin
Affiliations

The correlations of LMX1A and osteopontin expression to the clinicopathologic stages in pancreatic adenocarcinoma

Wen-Chiuan Tsai et al. Appl Immunohistochem Mol Morphol. 2013 Oct.

Abstract

Aim: To test the association of LMX1A and osteopontin (OPN) expression with histologic differentiation or pathologic stage in pancreatic ductal adenocarcinoma.

Methods: Immunohistochemical analysis was performed to determine LMX1A and OPN expression in 100 surgical specimens obtained from Chinese patients with well-differentiated (n=15), moderately differentiated (n=65), and poorly differentiated (n=20) pancreatic ductal adenocarcinomas.

Results: LMX1A and OPN immunoreactivities were undetectable in normal pancreatic glandular epithelia. Stronger immunostaining for LMX1A and OPN was associated with advanced nuclear grades of pancreatic ductal adenocarcinomas (70.7 and 87.1 for grade I, 109.8 and 118.3 for grade II, and 171.3 and 183.8 for grade III), and advanced TNM and American Joint Committee on Cancer stages of pancreatic ductal adenocarcinomas.

Conclusions: A higher expression of LMX1A and OPN is well correlated with histologic grade and pathologic stage of pancreatic ductal adenocarcinomas.

PubMed Disclaimer

Publication types

MeSH terms