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. 2012 Oct;73(4):219-23.
doi: 10.4046/trd.2012.73.4.219. Epub 2012 Oct 31.

Prevalence of Latent Tuberculosis Infection among Medical Students in South Korea

Da Ho Jung  1 , Kyung-Wook Jo, Tae Sun Shim
Affiliations

Prevalence of Latent Tuberculosis Infection among Medical Students in South Korea

Da Ho Jung et al. Tuberc Respir Dis (Seoul). 2012 Oct.

Abstract

Background: We investigated the prevalence of latent tuberculosis infection (LTBI) among medical students in South Korea.

Methods: Students from one medical school, who were in second- or third-year classes before clerkship course, were enrolled for three consecutive years in the study. A standard questionnaire was given to each participant, and tuberculin skin test (TST), QuantiFERON-TB GOLD In-Tube (QFT-GIT) assay, and chest radiography were performed.

Results: A total of 153 participants were enrolled in the study. The mean age of the subjects was 21.9±0.9 years, 105 (68.6%) were male, and 132 (86.3%) had been vaccinated with Bacille Calmette-Guerin (BCG). Four students (2.6%) had a history of contact with tuberculosis (TB) patients during medical practice. No abnormal chest radiograph findings were found for any of the subjects. Of the 153 subjects, 23 (15.0%) tested positive for the TST, and 8 (5.2%) tested positive for the QFT-GIT. The agreement between the two tests was determined to be 0.34 using kappa coefficients. Of the four students who had a history of contact with TB patients, only one subject tested positive for both tests, and the other three students tested negative for both tests.

Conclusion: A low prevalence of LTBI was found among medical students before clerkship course in South Korea.

Keywords: Interferon-gamma Release Tests, Schools, Medical; Latent Tuberculosis; Students; Tuberculin Test.

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Figures

Figure 1
Figure 1
Scatter plot of individual responses of the TST and QFT-GIT in medical students. The dashed line represents the cutoff of 0.35 IU/mL for interferon-gamma. All points below zero for QTF-GIT results in this figure have been assigned a value of zero. TST: tuberculin skin test; QFT-GIT: QuantiFERON-TB Gold In-Tube.
See this image and copyright information in PMC

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