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Review
. 2012 Oct;10(10):2312-2321.
doi: 10.3390/md10102312. Epub 2012 Oct 19.

Current status on marine products with reversal effect on cancer multidrug resistance

Ioana Abraham  1 , Khalid El Sayed  2 , Zhe-Sheng Chen  1 , Huiqin Guo  3
Affiliations
Review

Current status on marine products with reversal effect on cancer multidrug resistance

Ioana Abraham et al. Mar Drugs. 2012 Oct.

Abstract

The resistance of tumor cells to a broad range of anticancer agents continues to be a problem for the success of cancer chemotherapy. Multidrug resistance (MDR) is due in part to three drug transporter proteins: ABCB1/P-glycoprotein (P-gp), ABCC1/multidrug resistance protein 1 (MRP1) and ABCG2/breast cancer resistance protein (BCRP). These transporters are part of the ATP-binding cassette (ABC) superfamily, whose members function as ATP-dependent drug-efflux pumps. Their activity can be blocked by various drugs such as verapamil (calcium channel blocker) and cyclosporin A (immunosuppressive agent), etc. These compounds are called MDR modulators or reversals. This review highlights several marine natural products with reversal effect on multidrug resistance in cancer, including agosterol A, ecteinascidin 743, sipholane triterpenoids, bryostatin 1, and welwitindolinones.

Keywords: ABC transporters; marine natural products; multidrug resistance.

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Figures

Figure 1
Figure 1
Structure of marine natural products with reversal effect on multidrug resistance in cancer cells.
See this image and copyright information in PMC

References

    1. Haefner B. Drugs from the deep: Marine natural products as drug candidates. Drug Discov. Today. 2003;8:536–544. doi: 10.1016/S1359-6446(03)02713-2. - DOI - PubMed
    1. Paterson I., Anderson E.A. Chemistry. The renaissance of natural products as drug candidates. Science. 2005;310:451–453. doi: 10.1126/science.1116364. - DOI - PubMed
    1. Sithranga B.N., Kathiresan K. Anticancer drugs from marine flora: An overview. J. Oncol. 2010;2010:214186. - PMC - PubMed
    1. Hu G.P., Yuan J., Sun L., She Z.G., Wu J.H., Lan X.J., Zhu X., Lin Y.C., Chen S.P. Statistical research on marine natural products based on data obtained between 1985 and 2008. Mar. Drugs. 2011;9:514–525. doi: 10.3390/md9040514. - DOI - PMC - PubMed
    1. Mayer A.M., Glaser K.B., Cuevas C., Jacobs R.S., Kem W., Little R.D., McIntosh J.M., Newman D.J., Potts B.C., Shuster D.E. The odyssey of marine pharmaceuticals: A current pipeline perspective. Trends Pharmacol. Sci. 2010;31:255–265. doi: 10.1016/j.tips.2010.02.005. - DOI - PubMed

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