Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Oct;10(10):2337-2348.
doi: 10.3390/md10102337. Epub 2012 Oct 22.

Effects of oral administration of fucoidan extracted from Cladosiphon okamuranus on tumor growth and survival time in a tumor-bearing mouse model

Kazuo Azuma  1 , Toshitsugu Ishihara  1 , Hiroyuki Nakamoto  1 , Takao Amaha  1 , Tomohiro Osaki  1 , Takeshi Tsuka  1 , Tomohiro Imagawa  1 , Saburo Minami  1 , Osamu Takashima  2 , Shinsuke Ifuku  3 , Minoru Morimoto  3 , Hiroyuki Saimoto  3 , Hitoshi Kawamoto  4 , Yoshiharu Okamoto  1
Affiliations

Effects of oral administration of fucoidan extracted from Cladosiphon okamuranus on tumor growth and survival time in a tumor-bearing mouse model

Kazuo Azuma et al. Mar Drugs. 2012 Oct.

Abstract

We evaluated the anti-tumor activities of the oral administration of fucoidan extracted from Cladosiphon okamuranus using a tumor (colon 26)-bearing mouse model. The materials used included low-molecular-weight fucoidan (LMWF: 6.5-40 kDa), intermediate-molecular-weight fucoidan (IMWF: 110-138 kDa) and high-molecular-weight fucoidan (HMWF: 300-330 kDa). The IMWF group showed significantly suppressed tumor growth. The LMWF and HMWF groups showed significantly increased survival times compared with that observed in the control group (mice fed a fucoidan-free diet). The median survival times in the control, LMWF, IMWF and HMWF groups were 23, 46, 40 and 43 days, respectively. It was also found that oral administration of fucoidan increased the population of natural killer cells in the spleen. Furthermore, from the results of the experiment using Myd-88 knockout mice, it was found that these effects are related to gut immunity. These results suggest that fucoidan is a candidate anti-tumor functional food.

Keywords: Cladosiphon okamuranu; anti-tumor activities; colon-26; fucoidan; functional food; mice.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Effects of fucoidan on tumor tissue weights. Date represent the mean ± S.D. n = 5 in the low-molecular-weight fucoidan (LMWF), intermediate-molecular-weight fucoidan (IMWF) and high-molecular-weight fucoidan (HMWF) groups, n = 10 in the control group. * p < 0.05 compared to the control group, Turkey-Kramer’s test.
Figure 2
Figure 2
Effects of oral administration of fucoidan on survival times. n = 4 in each group. p < 0.05 compared to the control group in the LMWF and HMWF groups by Longrank test.
Figure 3
Figure 3
The effects of oral administration of fucoidan on murine splenic natural killer (NK) cell populations. The data represent the mean ± S.D. n = 3 of each group. * p < 0.05 compared to the control group, Tukey-Kramer’s test.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Li B., Lu F., Wei X., Zhao R. Fucoidan: Structure and bioactivity. Molecules. 2008;13:1671–1695. doi: 10.3390/molecules13081671. - DOI - PMC - PubMed
    1. Bilan M.I., Grachev A.A., Ustuzhanina N.E., Shashkov A.S., Nifantiev N.E., Usov A.I. Structure of a fucoidan from the brown seaweed Fucus evanescens C. Ag. Carbohydr. Res. 2002;337:719–730. doi: 10.1016/S0008-6215(02)00053-8. - DOI - PubMed
    1. Bilan M.I., Grachev A.A., Shashkov A.S., Nifantiev N.E., Usov A.I. Structure of a fucoidan from the brown seaweed Fucus serratus L. Carbohydr. Res. 2006;341:238–245. doi: 10.1016/j.carres.2005.11.009. - DOI - PubMed
    1. Hayashi K., Nakano T., Hashimoto M., Kanekiyo K., Hayashi T. Defensive effects of a fucoidan from brown alga Undaria pinnatifida against herpes simplex virus infection. Int. Immunopharmacol. 2008;8:109–116. doi: 10.1016/j.intimp.2007.10.017. - DOI - PubMed
    1. Cumashi A., Ushakova N.A., Preobrazhenskaya M.E., D’Incecco A., Piccoli A., Totani L., Tinari N., Morozevich G.E., Berman A.E., Bilan M.I., et al. A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds. Glycobiology. 2007;17:541–552. - PubMed

MeSH terms

LinkOut - more resources