Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Oct;6(4):452-6.
doi: 10.5009/gnl.2012.6.4.452. Epub 2012 Oct 18.

Rifaximin Plus Levofloxacin-Based Rescue Regimen for the Eradication of Helicobacter pylori

Sang-Pil Yun  1 , Han Gyung Seon, Chang Soo Ok, Kwang Ho Yoo, Min Kyung Kang, Won Hee Kim, Chang Il Kwon, Kwang Hyun Ko, Seong Gyu Hwang, Pil Won Park, Sung Pyo Hong
Affiliations

Rifaximin Plus Levofloxacin-Based Rescue Regimen for the Eradication of Helicobacter pylori

Sang-Pil Yun et al. Gut Liver. 2012 Oct.

Abstract

Background/aims: This study assessed the efficacy of a rifaximin plus levofloxacin-based rescue regimen in patients that had failed both triple and quadruple standard regimens for the eradication of Helicobacter pylori.

Methods: We treated patients for H. pylori between August 2009 and April 2011. The triple regimen consisted of combined treatment with amoxicillin, clarithromycin, and pantoprazole for 1 week. For failed cases, a quadruple regimen of tetracycline, metronidazole, bismuth dicitrate, and lansoprazole for 1 week was administered. The rescue regimen for persistently refractory cases was rifaximin 200 mg t.i.d., levofloxacin 500 mg q.d., and lansoprazole 15 mg b.i.d. for 1 week.

Results: In total, 482 patients were enrolled in this study. The eradication rates associated with the first and second regimens were 58% and 60%, respectively. Forty-seven out of 58 patients who failed with the second-line regimen received rifaximin plus levofloxacin-based third-line therapy. The eradication rate for the third regimen was 65%. The cumulative eradication rates were 58%, 85%, and 96% for each regimen, respectively.

Conclusions: A rifaximin plus levofloxacin-based regimen could be an alternative rescue therapy in patients with resistance to both triple and quadruple regimens for the eradication of H. pylori.

Keywords: Eradication; Helicobacter pylori; Rifaximin.

PubMed Disclaimer

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Enrollment and follow-up (F/U).
Fig. 2
Fig. 2
Cumulative eradication rates of Helicobacter pylori (per protocol).
See this image and copyright information in PMC

References

    1. Malfertheiner P, Mégraud F, O'Morain C, et al. Current concepts in the management of Helicobacter pylori infection: the Maastricht 2-2000 Consensus Report. Aliment Pharmacol Ther. 2002;16:167–180. - PubMed
    1. Scarpignato C. Towards the ideal regimen for Helicobacter pylori eradication: the search continues. Dig Liver Dis. 2004;36:243–247. - PubMed
    1. Romano M, Cuomo A. Eradication of Helicobacter pylori: a clinical update. MedGenMed. 2004;6:19. - PMC - PubMed
    1. McLoughlin RM, O'Morain CA, O'Connor HJ. Eradication of Helicobacter pylori: recent advances in treatment. Fundam Clin Pharmacol. 2005;19:421–427. - PubMed
    1. Candelli M, Nista EC, Carloni E, et al. Treatment of H. pylori infection: a review. Curr Med Chem. 2005;12:375–384. - PubMed

LinkOut - more resources