Clinical management of filovirus-infected patients

doi:10.3390/v4091668

Review

. 2012 Sep;4(9):1668-86.

doi: 10.3390/v4091668. Epub 2012 Sep 21.

Clinical management of filovirus-infected patients

Danielle V Clark¹, Peter B Jahrling, James V Lawler

Affiliations

PMID: 23170178
PMCID: PMC3499825
DOI: 10.3390/v4091668

Review

Clinical management of filovirus-infected patients

Danielle V Clark et al. Viruses. 2012 Sep.

. 2012 Sep;4(9):1668-86.

doi: 10.3390/v4091668. Epub 2012 Sep 21.

Authors

Danielle V Clark¹, Peter B Jahrling, James V Lawler

Affiliation

¹ NIH/NIAID Integrated Research Facility, Fort Detrick, MD, USA. Danielle.clark.ctr@med.navy.mil

PMID: 23170178
PMCID: PMC3499825
DOI: 10.3390/v4091668

Abstract

Filovirus infection presents many unique challenges to patient management. Currently no approved treatments are available, and the recommendations for supportive care are not evidence based. The austere clinical settings in which patients often present and the sporadic and at times explosive nature of filovirus outbreaks have effectively limited the information available to evaluate potential management strategies. This review will summarize the management approaches used in filovirus outbreaks and provide recommendations for collecting the information necessary for evaluating and potentially improving patient outcomes in the future.

Keywords: Clinical management; Ebola; Filoviruses; Marburg; Outbreak; Treatment.

PubMed Disclaimer

Cited by

Marburg Virus Disease: A Narrative Review.
Letafati A, Fakhr SSH, Najafabadi AQ, Karami N, Karami H. Letafati A, et al. Health Sci Rep. 2025 May 6;8(5):e70669. doi: 10.1002/hsr2.70669. eCollection 2025 May. Health Sci Rep. 2025. PMID: 40330770 Free PMC article.
Ebola virus disease in nonendemic countries.
Wong SS, Wong SC. Wong SS, et al. J Formos Med Assoc. 2015 May;114(5):384-98. doi: 10.1016/j.jfma.2015.01.012. Epub 2015 Apr 13. J Formos Med Assoc. 2015. PMID: 25882189 Free PMC article. Review.
Mechanism of Binding to Ebola Virus Glycoprotein by the ZMapp, ZMAb, and MB-003 Cocktail Antibodies.
Davidson E, Bryan C, Fong RH, Barnes T, Pfaff JM, Mabila M, Rucker JB, Doranz BJ. Davidson E, et al. J Virol. 2015 Nov;89(21):10982-92. doi: 10.1128/JVI.01490-15. Epub 2015 Aug 26. J Virol. 2015. PMID: 26311869 Free PMC article.
Successful delivery of RRT in Ebola virus disease.
Connor MJ Jr, Kraft C, Mehta AK, Varkey JB, Lyon GM, Crozier I, Ströher U, Ribner BS, Franch HA. Connor MJ Jr, et al. J Am Soc Nephrol. 2015 Jan;26(1):31-7. doi: 10.1681/ASN.2014111057. Epub 2014 Nov 14. J Am Soc Nephrol. 2015. PMID: 25398785 Free PMC article.
Outbreaks of Ebola virus disease in Africa: the beginnings of a tragic saga.
Chippaux JP. Chippaux JP. J Venom Anim Toxins Incl Trop Dis. 2014 Oct 3;20(1):44. doi: 10.1186/1678-9199-20-44. eCollection 2014. J Venom Anim Toxins Incl Trop Dis. 2014. PMID: 25320574 Free PMC article. Review.

See all "Cited by" articles

References

1. Kortepeter M.G., Bausch D.G., Bray M. Basic clinical and laboratory features of filoviral hemorrhagic fever. J. Infect. Dis. 2011;204(Suppl 3):S810–S816. doi: 10.1093/infdis/jir299. - DOI - PubMed
1. Ndambi R., Akamituna P., Bonnet M.J., Tukadila A.M., Muyembe-Tamfum J.J., Colebunders R. Epidemiologic and clinical aspects of the Ebola virus epidemic in Mosango, Democratic Republic of the Congo, 1995. J. Infect. Dis. 1999;179 (Suppl 1):S8–S10. - PubMed
1. Bwaka M.A., Bonnet M.J., Calain P., Colebunders R., De Roo A., Guimard Y., Katwiki K.R., Kibadi K., Kipasa M.A., Kuvula K.J. Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients. J. Infect. Dis. 1999;179(Suppl 1):S1–S7. doi: 10.1086/314568. - DOI - PubMed
1. Zaki S.R., Goldsmith C.S. Pathologic features of filovirus infections in humans. Curr. Top. Microbiol. Immunol. 1999;235:97–116. - PubMed
1. Ndayimirije N., Kindhauser M.K. Marburg hemorrhagic fever in Angola--fighting fear and a lethal pathogen. N. Engl. J. Med. 2005;352:2155–2157. doi: 10.1056/NEJMp058115. - DOI - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources

[1] Kortepeter M.G., Bausch D.G., Bray M. Basic clinical and laboratory features of filoviral hemorrhagic fever. J. Infect. Dis. 2011;204(Suppl 3):S810–S816. doi: 10.1093/infdis/jir299. - DOI - PubMed

[2] Kortepeter M.G., Bausch D.G., Bray M. Basic clinical and laboratory features of filoviral hemorrhagic fever. J. Infect. Dis. 2011;204(Suppl 3):S810–S816. doi: 10.1093/infdis/jir299. - DOI - PubMed

[3] Ndambi R., Akamituna P., Bonnet M.J., Tukadila A.M., Muyembe-Tamfum J.J., Colebunders R. Epidemiologic and clinical aspects of the Ebola virus epidemic in Mosango, Democratic Republic of the Congo, 1995. J. Infect. Dis. 1999;179 (Suppl 1):S8–S10. - PubMed

[4] Ndambi R., Akamituna P., Bonnet M.J., Tukadila A.M., Muyembe-Tamfum J.J., Colebunders R. Epidemiologic and clinical aspects of the Ebola virus epidemic in Mosango, Democratic Republic of the Congo, 1995. J. Infect. Dis. 1999;179 (Suppl 1):S8–S10. - PubMed

[5] Bwaka M.A., Bonnet M.J., Calain P., Colebunders R., De Roo A., Guimard Y., Katwiki K.R., Kibadi K., Kipasa M.A., Kuvula K.J. Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients. J. Infect. Dis. 1999;179(Suppl 1):S1–S7. doi: 10.1086/314568. - DOI - PubMed

[6] Bwaka M.A., Bonnet M.J., Calain P., Colebunders R., De Roo A., Guimard Y., Katwiki K.R., Kibadi K., Kipasa M.A., Kuvula K.J. Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients. J. Infect. Dis. 1999;179(Suppl 1):S1–S7. doi: 10.1086/314568. - DOI - PubMed

[7] Zaki S.R., Goldsmith C.S. Pathologic features of filovirus infections in humans. Curr. Top. Microbiol. Immunol. 1999;235:97–116. - PubMed

[8] Zaki S.R., Goldsmith C.S. Pathologic features of filovirus infections in humans. Curr. Top. Microbiol. Immunol. 1999;235:97–116. - PubMed

[9] Ndayimirije N., Kindhauser M.K. Marburg hemorrhagic fever in Angola--fighting fear and a lethal pathogen. N. Engl. J. Med. 2005;352:2155–2157. doi: 10.1056/NEJMp058115. - DOI - PubMed

[10] Ndayimirije N., Kindhauser M.K. Marburg hemorrhagic fever in Angola--fighting fear and a lethal pathogen. N. Engl. J. Med. 2005;352:2155–2157. doi: 10.1056/NEJMp058115. - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Clinical management of filovirus-infected patients

Affiliation

Clinical management of filovirus-infected patients

Authors

Affiliation

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources