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Review
. 2012 Sep;4(9):1802-29.
doi: 10.3390/v4091802. Epub 2012 Sep 24.

Animal models, prophylaxis, and therapeutics for arenavirus infections

Eric Vela  1
Affiliations
Review

Animal models, prophylaxis, and therapeutics for arenavirus infections

Eric Vela. Viruses. 2012 Sep.

Abstract

Arenaviruses are enveloped, bipartite negative single-stranded RNA viruses that can cause a wide spectrum of disease in humans and experimental animals including hemorrhagic fever. The majority of these viruses are rodent-borne and the arenavirus family can be divided into two groups: the Lassa-Lymphocytic choriomeningitis serocomplex and the Tacaribe serocomplex. Arenavirus-induced disease may include characteristic symptoms ranging from fever, malaise, body aches, petechiae, dehydration, hemorrhage, organ failure, shock, and in severe cases death. Currently, there are few prophylactic and therapeutic treatments available for arenavirus-induced symptoms. Supportive care and ribavirin remain the predominant strategies for treating most of the arenavirus-induced diseases. Therefore, efficacy testing of novel therapeutic and prophylactic strategies in relevant animal models is necessary. Because of the potential for person-to-person spread, the ability to cause lethal or debilitating disease in humans, limited treatment options, and potential as a bio-weapon, the development of prophylactics and therapeutics is essential. This article reviews the current arenavirus animal models and prophylactic and therapeutic strategies under development to treat arenavirus infection.

Keywords: Animal Models; Arenavirus; Hemorrhagic Fever; Prophylaxis; Therapeutics.

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References

    1. Jay M.T., Glaser C., Fulhorst C.F. The Arenaviruses. JAVMA. 2005;227:904–915. doi: 10.2460/javma.2005.227.904. - DOI - PubMed
    1. Price J.L. Serological evidence of infection of Tacaribe virus and arboviruses in Trinidadian bats. Am. J. Trop. Med. Hyg. 1978;27:162–167. - PubMed
    1. Buchmeier M.J., de la Torre J.-C., Peters C.J. Arenaviridae: The Viruses and Their Replication. In: Knipe D.M., Howley P.M., editors. Fields Virology. Lippincott Williams & Wilkins; Philadelphia, PA, USA: 2007. pp. 1791–1827.
    1. Gowen B., Holbrook M.R. Animal Models of highly pathogenic RNA viral infecitons: Hemorrhagic fever viruses. Antivir Res. 2008;78:79–90. - PubMed
    1. U.S Department of Health and Human Services. Biosafety in Microbiology and Biomedical Laboratories. 5th. U.S. Government Printing Office; Washington, DC, USA: 2007.

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