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. 1990 Feb;65(2):196-200.
doi: 10.1136/adc.65.2.196.

Pharmacokinetics of prednisolone in children with nephrosis

P F Miller  1 , C J Bowmer, J Wheeldon, J T Brocklebank
Affiliations

Pharmacokinetics of prednisolone in children with nephrosis

P F Miller et al. Arch Dis Child. 1990 Feb.

Abstract

The pharmacokinetics of prednisolone given intravenously were studied in 11 children with relapsed steroid responsive nephrotic syndrome, and four control subjects. The clearance of both total and unbound drug was decreased in these children and the unbound fraction of the drug in plasma was significantly correlated with the degree of hypoalbuminaemia. We conclude that changes in the clearance of prednisolone and altered protein binding might account for some of the variability in both therapeutic responses and the incidence of toxicity in patients treated with standard dosage regimens.

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References

    1. Lancet. 1971 Oct 9;2(7728):778-80 - PubMed
    1. J Pharm Sci. 1976 Jul;65(7):1006-10 - PubMed
    1. Clin Pharmacokinet. 1976;1(1):2-24 - PubMed
    1. J Pediatr. 1978 Aug;93(2):299-303 - PubMed
    1. Br J Clin Pharmacol. 1982 Nov;14(5):667-72 - PubMed

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