Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Nov 21;16(6):178.
doi: 10.1186/cc11834.

Glycemic variability is complex--is glucose complexity variable?

Roosmarijn T M van Hooijdonk, Ameen Abu-Hanna, Marcus J Schultz
Comment

Glycemic variability is complex--is glucose complexity variable?

Roosmarijn T M van Hooijdonk et al. Crit Care. .

Abstract

Observational studies show an independent association between increased glycemic variability and higher mortality in critically ill patients. Minimization of glycemic variability is therefore suggested as a new target of glycemic control, which may require very frequent or almost continuous monitoring of glucose levels. Brunner and colleagues show the use of real-time subcutaneous continuous glucose monitoring does not decrease glycemic variability. Continuous glucose monitoring, however, may reveal changes in glucose complexity, which may be of interest since both increased and decreased glucose complexity is associated with higher mortality in the critically ill.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schematic view of the four domains of blood glucose control. [1] hyperglycemia, [2] hypoglycemia, [3] glycemic variability, and [4] glucose complexity. CGM, continuous glucose monitoring.
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Brunner R, Adelsmayr G, Herkner H, Madl C, Holzinger U. Glycemic variability and glucose complexity in critically ill patients: a retrospective analysis of continuous glucose monitoring data. Crit Care. 2012;16:R175. doi: 10.1186/cc11657. - DOI - PMC - PubMed
    1. Holzinger U, Warszawska J, Kitzberger R, Herkner H, Metnitz PG, Madl C. Impact of shock requiring norepinephrine on the accuracy and reliability of subcutaneous continuous glucose monitoring. Intensive Care Med. 2009;16:1383–1389. doi: 10.1007/s00134-009-1471-y. - DOI - PubMed
    1. Holzinger U, Warszawska J, Kitzberger R, Wewalka M, Miehsler W, Herkner H, Madl C. Real-time continuous glucose monitoring in critically ill patients: a prospective randomized trial. Diabetes Care. 2010;16:467–472. doi: 10.2337/dc09-1352. - DOI - PMC - PubMed
    1. Krinsley JS. Glycemic variability: a strong independent predictor of mortality in critically ill patients. Crit Care Med. 2008;16:3008–3013. doi: 10.1097/CCM.0b013e31818b38d2. - DOI - PubMed
    1. Hermanides J, Vriesendorp TM, Bosman RJ, Zandstra DF, Hoekstra JB, Devries JH. Glucose variability is associated with intensive care unit mortality. Crit Care Med. 2010;16:838–842. doi: 10.1097/CCM.0b013e3181cc4be9. - DOI - PubMed