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. 2013 Jan 7;52(2):593-6.
doi: 10.1002/anie.201207561. Epub 2012 Nov 22.

Asymmetric hydrogenation of α,α'-disubstituted cycloketones through dynamic kinetic resolution: an efficient construction of chiral diols with three contiguous stereocenters

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Asymmetric hydrogenation of α,α'-disubstituted cycloketones through dynamic kinetic resolution: an efficient construction of chiral diols with three contiguous stereocenters

Chong Liu et al. Angew Chem Int Ed Engl. .

Abstract

Chiral diols with three contiguous stereocenters were synthesized by a highly enantioselective ruthenium-catalyzed asymmetric hydrogenation of racemic α,α'-disubstituted cycloketones involving dynamic kinetic resolution. This new catalytic asymmetric method provides a concise route to the alkaloid (+)-γ-lycorane.

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