Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012;2(4):301-8.
Epub 2012 Oct 25.

Safety and efficacy of the Aperio thrombectomy device when compared to the Solitaire AB/FR and the Revive devices in a pulsatile flow system

Mahdi Saleh  1 , John Nathan Spence, Sanjeev Nayak, Gillian Pearce, Christopher Tennuci, Christine Roffe
Affiliations

Safety and efficacy of the Aperio thrombectomy device when compared to the Solitaire AB/FR and the Revive devices in a pulsatile flow system

Mahdi Saleh et al. Am J Cardiovasc Dis. 2012.

Abstract

Background and purpose: There are a limited number of studies comparing the Aperio mechanical thrombectomy device to other stent-based devices. In this paper, we compared the Aperio thrombectomy device to the Solitaire AB, FR and Revive devices in a model of the middle cerebral artery (MCA) within a modified pulsatile flow system.

Methods: Thrombi made of lamb's blood were placed into a pulsatile flow system perfused with Hartmann's solution at 80 bpm with a mean pressure of 90 mm Hg. 30 experiments were run with each device.

Results: Recanalization rates were similar for all three devices (90% with the Solitaire AB, FR, 80% with the Revive, and 90% with the Aperio). The mean number of attempts to retrieve the thrombus was also similar for all three devices (1.7 with the Solitaire AB, FR, 2.1 with the Revive, 1.6 with the Aperio). Clot fragmentation and embolization rates revealed no statistical significance but there was a trend towards lower embolization rates with the Aperio (23% compared to 40% with the Solitaire AB, FR and 47% with the Revive). The Aperio was the fastest to recanalize the MCA (mean of 66 seconds compared to 186 seconds for the Solitaire AB, FR and 169 seconds for the Revive).

Conclusions: In this in vitro setting, the Aperio device seems to be an efficacious and safe device when compared to other similar clinically used mechanical thrombectomy devices. Larger clinical trials are warranted.

Keywords: Aperio; Revive; Solitaire; Stroke; flow model; mechanical thrombectomy; recanalization.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The three stent-based mechanical thrombectomy devices. Pictured from top to bottom: the Solitaire AB, FR, the Revive, and the Aperio. Devices are not to scale.
Figure 2
Figure 2
The target area occluded within the model middle cerebral artery.
Figure 3
Figure 3
Schematic diagram of the flow system.
Figure 4
Figure 4
On the left, is a recovered filter with emboli shown after use of the Aperio. On the right, is a clean filter for comparison. Each filter was 5 mm in diameter.
See this image and copyright information in PMC

References

    1. Wolfe CD. The impact of stroke. Br Med Bull. 2000;56:275–286. - PubMed
    1. Thomassen L, Bakke SJ. Endovascular reperfusion therapy in acute ischaemic stroke. Acta Neurol Scand. 2007;187:22–29. - PubMed
    1. Tekle WG, Chaudhry SA, Fatima Z, Ahmed M, Khalil S, Hassan AE, Rodriguez GJ, Suri FK, Qureshi AI. Intravenous Thrombolysis in Expanded Time Window (3-4.5 hours) in General Practice with Concurrent Availability of Endovascular Treatment. J Vasc Interv Neurol. 2012;5:22–26. - PMC - PubMed
    1. Wardlaw JM, Murray V, Berge E, Del Zoppo GJ. Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev. 2009;4:CD000213. - PubMed
    1. IST-collaborative group. The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3] ): a randomised controlled trial. Lancet. 2012;379:2352–2363. - PMC - PubMed

LinkOut - more resources