Neck circumference and central obesity are independent predictors of coronary artery disease in patients undergoing coronary angiography

Abstract

Excess of adiposity is a risk factor for coronary artery disease, but it remains unclear if the distribution of fat is an effect modifier or if the risk is mediate by hypertension, diabetes and dyslipidemia. We investigated the association of central in addition to general obesity with coronary artery disease (CAD). A case-control study was conducted in 376 patients, aged 40 years or more, with chronic coronary disease, undergoing elective coronary angiography. Excess of adiposity was evaluated by the Body Mass Index (BMI), waist circumference, waist-hip ratio, and neck circumference. Cases (n=155) were patients referred for coronary angiography with at least 50% of coronary stenosis in at least one epicardial vessels or their branches, with diameter greater than 2.5 mm. Controls (n=221) were patients referred for coronary angiography without significant coronary disease. Odds ratios and 95%CI for significant coronary stenosis were calculated using multiple logistic regression, controlling for age, sex, years at school, smoking, hypertension, HDL-cholesterol, diabetes mellitus, and an adiposity index. There was a predominance of men and individuals older than 50 years among cases. The waist-hip ratio increased four times the chance of CAD, even after the control for confounding factors, including BMI. Neck circumference above the 90(th) Percentile doubled the chance of CAD, after adjustment for traditional risk factors. Neck circumference and waist-hip ratio are independent predictors of CAD, even taking into account traditional risk factors for CAD. These findings highlight the need of anthropometric assessment among patients with suspected coronary artery disease.

Keywords: Obesity; abdominal obesity; central obesity; coronary angiography; coronary artery disease.

Figure 1

Neck circumference according to the number of coronary arteries with significant stenosis (CAD; at least one coronary artery with ≥50% diameter stenosis involving either on major epicardial vessels or any branches with >2.5 mm diameter).

Figure 2

Waist-hip ratio according to the number ofcoronary arteries with significant stenosis (CAD; atleast one coronary artery with ≥50% diameter stenosisinvolving either on major epicardial vessels or anybranches with >2.5 mm diameter).