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Review
. 2012;12 Suppl 2(Suppl 2):S6.
doi: 10.1186/1471-2334-12-S2-S6. Epub 2012 Nov 12.

Natural history and clinical response: "it's the virus, stupid, or is it the host?"

Stefania Nucara  1 , Benedetto Caroleo, Vincenzo Guadagnino, Nicola Perrotti, Francesco Trapasso
Affiliations
Review

Natural history and clinical response: "it's the virus, stupid, or is it the host?"

Stefania Nucara et al. BMC Infect Dis. 2012.

Abstract

A major goal of modern medicine is the application of personalized therapies, consisting of decisions and practices tailored to the individual patient. Information about genetic variants, either mutant or polymorphic, represents the basis for the development of this clinical approach. Recently, several independent genome-wide association studies (GWAS) have identified two single nucleotide polymorphisms (SNPs) on the IL28B locus associated with HCV containment, spontaneous clearance, treatment response, and disease progression. In this minireview we will concisely discuss some critical genetic concepts that may have possible implications for clinical decisions in the treatment of HCV infection.

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