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Clinical Trial
. 2012;12 Suppl 1(Suppl 1):S5.
doi: 10.1186/1471-2482-12-S1-S5. Epub 2012 Nov 15.

Morpho-functional gastric pre-and post-operative changes in elderly patients undergoing laparoscopic cholecystectomy for gallstone related disease

Giovanni Aprea  1 , Alfonso Canfora, Antonio Ferronetti, Antonio Giugliano, Francesco Guida, Antonio Braun, Melania Battaglini Ciciriello, Federica Tovecci, Giovanni Mastrobuoni, Fabrizio Cardin, Bruno Amato
Affiliations
Clinical Trial

Morpho-functional gastric pre-and post-operative changes in elderly patients undergoing laparoscopic cholecystectomy for gallstone related disease

Giovanni Aprea et al. BMC Surg. 2012.

Abstract

Background: Cholecystectomy, gold standard treatment for gallbladder lithiasis, is closely associated with increased bile reflux into the stomach as amply demonstrated by experimental studies. The high prevalence of gallstones in the population and the consequent widespread use of surgical removal of the gallbladder require an assessment of the relationship between cholecystectomy and gastric mucosal disorders.Morphological evaluations performed on serial pre and post - surgical biopsies have provided new acquisitions about gastric damage induced by bile in the organ.

Methods: 62 elderly patients with gallstone related disease were recruited in a 30 months period. All patients were subjected to the most appropriate treatment (Laparoscopic cholecystectomy). The subjects had a pre-surgical evaluation with:• dyspeptic symptoms questionnaire,• gastric endoscopy with body, antrum, and fundus random biopsies,• histo-pathological analysis of samples and elaboration of bile reflux index (BRI).The same evaluation was repeated at a 6 months follow-up.

Results: In our series the duodeno-gastric reflux and the consensual biliary gastritis, assessed histologically with the BRI, was found in 58% of the patients after 6 months from cholecystectomy. The demonstrated bile reflux had no effect on H. pylori's gastric colonization nor on the induction of gastric precancerous lesions.

Conclusions: Cholecystectomy, gold standard treatment for gallstone-related diseases, is practiced in a high percentage of patients with this condition. Such procedure, considered by many harmless, was, in our study, associated with a significant risk of developing biliary gastritis after 6 months during the postoperative period.

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Figures

Figure 1
Figure 1
BRI positive patients in pre- and post-operative phase
See this image and copyright information in PMC

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