Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012;12 Suppl 1(Suppl 1):S15.
doi: 10.1186/1471-2482-12-S1-S15. Epub 2012 Nov 15.

Use of statins in lower extremity artery disease: a review

Giuseppe Gargiulo  1 , Giuseppe Giugliano, Linda Brevetti, Anna Sannino, Gabriele Giacomo Schiattarella, Federica Serino, Andreina Carbone, Fernando Scudiero, Marco Ferrone, Roberto Corrado, Raffaele Izzo, Lorenzo Chiariotti, Cinzia Perrino, Bruno Amato, Bruno Trimarco, Giovanni Esposito
Affiliations
Review

Use of statins in lower extremity artery disease: a review

Giuseppe Gargiulo et al. BMC Surg. 2012.

Abstract

Background: Lower extremity artery disease (LE-PAD) is one of the most common manifestations of atherosclerosis, particularly in elderly patients, and it is related to a high cardiovascular risk.

Description: It is well established that statin therapy is characterized by crucial benefits on cardiovascular system by limiting atherosclerotic progression and reducing cardiovascular events and mortality. A growing body of evidence support efficacy of statins in LE-PAD due to the ability of both reducing cardiovascular risk and improving walking distance and, hence, quality of life. Consequently, statin therapy should be considered in all LE-PAD patients and new LDL-cholesterol targets should be reached.

Conclusions: Our opinion is that statin therapy remains still underutilized or with inadequate dosage, so therapy of LE-PAD patients should be improved to obtain all the demonstrated benefits of statins.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Tendera M, Aboyans V, Bartelink ML, Baumgartner I, Clement D, Collet JP, Cremonesi A, De Carlo M, Erbel R, Fowkes FG. et al.ESC Guidelines on the diagnosis and treatment of peripheral artery diseases: Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries: the Task Force on the Diagnosis and Treatment of Peripheral Artery Diseases of the European Society of Cardiology (ESC) Eur Heart J. 2011;32(22):2851–2906. - PubMed
    1. Giugliano G, Di Serafino L, Perrino C, Schiano V, Laurenzano E, Cassese S, De Laurentis M, Schiattarella GG, Brevetti L, Sannino A, Effects of successful percutaneous lower extremity revascularization on cardiovascular outcome in patients with peripheral arterial disease. Int J Cardiol. 2012. - PubMed
    1. Schiano V, Sirico G, Giugliano G, Laurenzano E, Brevetti L, Perrino C, Brevetti G, Esposito G. Femoral plaque echogenicity and cardiovascular risk in claudicants. JACC Cardiovasc Imaging. 2012;5(4):348–357. doi: 10.1016/j.jcmg.2012.01.011. - DOI - PubMed
    1. Perrino C, Gargiulo G, Pironti G, Franzone A, Scudiero L, De Laurentis M, Magliulo F, Ilardi F, Carotenuto G, Schiattarella GG. et al.Cardiovascular effects of treadmill exercise in physiological and pathological preclinical settings. Am J Physiol Heart Circ Physiol. 2011;300(6):H1983–1989. doi: 10.1152/ajpheart.00784.2010. - DOI - PubMed
    1. Indolfi C, Avvedimento EV, Rapacciuolo A, Di Lorenzo E, Esposito G, Stabile E, Feliciello A, Mele E, Giuliano P, Condorelli G. et al.Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo. Nat Med. 1995;1(6):541–545. doi: 10.1038/nm0695-541. - DOI - PubMed

MeSH terms

Substances