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. 2013 Apr;16(4):687-92.
doi: 10.1017/S1368980012003084. Epub 2012 Jul 16.

Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size

Shu Jun Song  1 , Shaoyan Si, Junli Liu, Xingming Chen, Ling Zhou, Guiyue Jia, Genlan Liu, Yujing Niu, Jie Wu, Wenying Zhang, Jianzhong Zhang
Affiliations

Vitamin D status in Chinese pregnant women and their newborns in Beijing and their relationships to birth size

Shu Jun Song et al. Public Health Nutr. 2013 Apr.

Abstract

Objective: To evaluate the prevalence of vitamin D deficiency in pregnant women and their newborns in Beijing, China and the influence of vitamin D deficiency on birth size.

Design: A cross-sectional study.

Setting: Data were collected from pregnant women who delivered during April to May 2010 at 306 Hospital of PLA in Beijing, China.

Subjects: Participants in the study were seventy healthy nulliparous pregnant women with singleton pregnancies who delivered healthy babies at full term and their newborns.

Results: Severe vitamin D deficiency (25-hydroxyvitamin D (25(OH)D) < 25 nmol/l) was detected in 54·5 % of mothers and 46·6 % of newborns. Neither mothers nor newborns had serum 25(OH)D concentrations that reached the normal level (>75 nmol/l). The concentration of 25(OH)D in mothers was positively correlated with that in cord blood (r = 0·89, P < 0·001). Newborns of mothers with severe vitamin D deficiency had lower birth length and birth weight. The head circumference and birth weight were lower in vitamin D-deficient newborns.

Conclusions: The study indicates that pregnant women and neonates residing in Beijing are at high risk of vitamin D deficiency. Neonatal 25(OH)D concentrations are dependently related to maternal 25(OH)D levels. Maternal and neonatal vitamin D status influences newborn size.

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Figures

Fig. 1
Fig. 1
Serum 25-hydroxyvitamin D (25(OH)D) concentrations in mothers and cord blood: scatter plot showing the relationship between maternal and cord blood serum 25(OH)D concentrations (n 58; r = 0·890, P = 0·000) among women and their newborns in Beijing, China, April–May 2010. Regression equation (by linear regression analysis): y = 0·8255x + 4·6145
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