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Review
. 2012 Dec;12(12):966-76.
doi: 10.1016/S1473-3099(12)70243-8.

Strategies to increase responsiveness to hepatitis B vaccination in adults with HIV-1

Jennifer A Whitaker  1 , Nadine G Rouphael, Srilatha Edupuganti, Lilin Lai, Mark J Mulligan
Affiliations
Review

Strategies to increase responsiveness to hepatitis B vaccination in adults with HIV-1

Jennifer A Whitaker et al. Lancet Infect Dis. 2012 Dec.

Abstract

HIV and hepatitis B virus co-infection leads to substantially increased morbidity and mortality compared with either infection alone. Immunisation with hepatitis B virus vaccine is the most effective way to prevent the infection in people with HIV; however, these patients have decreased vaccine responses and a short duration of protection compared with immunocompetent individuals. Control of HIV replication with highly active antiretroviral therapy and increased CD4 cell counts are associated with improved immune responses to hepatitis B vaccination. New vaccination strategies, such as increased vaccine dose, use of the intradermal route, and addition of adjuvants, could improve response rates in adults with HIV.

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References

    1. Alter MJ. Epidemiology of viral hepatitis and HIV co-infection. J Hepatol. 2006;44(1 suppl):S6–9. - PubMed
    1. World Health Organization [accessed Aug 24, 2012];Global Health Observatory: HIV/AIDS. http://www.who.int/gho/hiv/en/
    1. Spradling PR, Richardson JT, Buchacz K, Moorman AC, Brooks JT. Prevalence of chronic hepatitis B virus infection among patients in the HIV Outpatient Study, 1996–2007. J Viral Hepat. 2010;17:879–86. - PubMed
    1. Kellerman SE, Hanson DL, McNaghten AD, Fleming PL. Prevalence of chronic hepatitis B and incidence of acute hepatitis B infection in human immunodeficiency virus-infected subjects. J Infect Dis. 2003;188:571–77. - PubMed
    1. Lewden C, Salmon D, Morlat P, et al. Causes of death among human immunodeficiency virus (HIV)-infected adults in the era of potent antiretroviral therapy: emerging role of hepatitis and cancers, persistent role of AIDS. Int J Epidemiol. 2005;34:121–30. - PubMed

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