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. 2012 Nov 23;17(12):13937-47.
doi: 10.3390/molecules171213937.

Evaluation of the hepatoprotective Effects of Lantadene A, a pentacyclic triterpenoid of Lantana plants against acetaminophen-induced liver damage

Chong Grace-Lynn  1 , Yeng Chen, Lachimanan Yoga Latha, Jagat R Kanwar, Subramanion L Jothy, Soundararajan Vijayarathna, Sreenivasan Sasidharan
Affiliations

Evaluation of the hepatoprotective Effects of Lantadene A, a pentacyclic triterpenoid of Lantana plants against acetaminophen-induced liver damage

Chong Grace-Lynn et al. Molecules. .

Retraction in

Abstract

The aim of the present study was to evaluate the hepatoprotective activity of lantadene A against acetaminophen-induced liver toxicity in mice was studied. Activity was measured by monitoring the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin, along with histo-pathological analysis. Silymarin was used as positive control. A bimodal pattern of behavioural toxicity was exhibited by the lantadene A-treated group at the beginning of the treatment. However, treatment with lantadene A and silymarin resulted in an increase in the liver weight compared with the acetaminophen treated group. The results of the acetaminophen-induced liver toxicity experiments showed that mice treated with lantadene A (500 mg/kg) showed a significant decrease in the activity of ALT, AST and ALP and the level of bilirubin, which were all elevated in the acetaminophen treated group (p < 0.05). Histological studies supported the biochemical findings and a maximum improvement in the histoarchitecture was seen. The lantadene A-treated group showed remarkable protective effects against histopathological alterations, with comparable results to the silymarin treated group. The current study confirmed the hepatoprotective effects of lantadene A against the model hepatotoxicant acetaminophen, which is likely related to its potent antioxidative activity.

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Figures

Figure 1
Figure 1
Lantadene A.
Figure 2
Figure 2
Light microphotographs of control liver. (H: hepatocytes; N: nucleus; SS: sinusoid; CV: central vein).
Figure 3
Figure 3
Light microphotographs of liver cell of mice exposed to acetaminophen. (NP: Neutrophil; DS: dilated sinusoid; FN: focal necrosis; B: binucleated cells).
Figure 4
Figure 4
Light microphotographs of liver cells of mice treated with lantadene A (H: hepatocytes; N: nucleus; SS: sinusoid; CV: central vein).
Figure 5
Figure 5
Light microphotographs of liver cells of mice treated with silymarin (H: hepatocytes; N: nucleus; SS: sinusoid; CV: central vein).
See this image and copyright information in PMC

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