Bugs on the brain; brain in the gut--seeking explanations for common gastrointestinal symptoms
- PMID: 23179664
- DOI: 10.1007/s11845-012-0865-y
Bugs on the brain; brain in the gut--seeking explanations for common gastrointestinal symptoms
Abstract
Introduction: Gastrointestinal symptoms such as heartburn, indigestion (or dyspepsia), bloating, distension, constipation, abdominal pain, abdominal discomfort and diarrhoea are extremely common worldwide. For some, such symptoms can prove to be chronic and disabling.
Methods: The recent literature on irritable bowel syndrome and, in particular, work emanating form this authors research group, was reviewed.
Results: These functional symptoms commonly occur in aggregations, referred to as functional gastrointestinal disorders (FGIDs). Some of the FGIDs and, most notably irritable bowel syndrome (IBS), have achieved a degree of scientific and clinical credibility as coherent entities. Several lines of evidence ranging from gut motility to the microbiota are under investigation in attempts to explain IBS or its symptomatology.
Conclusion: Though biomarkers for IBS and other FGIDs have proven elusive, considerable progress has been made in understanding possible aetiological factors in IBS; progress which may well lead to better therapeutic strategies.
Similar articles
-
Therapeutic strategies for functional dyspepsia and irritable bowel syndrome based on pathophysiology.J Gastroenterol. 2015 Jun;50(6):601-13. doi: 10.1007/s00535-015-1076-x. Epub 2015 Apr 29. J Gastroenterol. 2015. PMID: 25917563 Review.
-
Evidence that independent gut-to-brain and brain-to-gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1-year population-based prospective study.Aliment Pharmacol Ther. 2016 Sep;44(6):592-600. doi: 10.1111/apt.13738. Epub 2016 Jul 22. Aliment Pharmacol Ther. 2016. PMID: 27444264
-
Multidimensionality of symptom complexes in irritable bowel syndrome and other functional gastrointestinal disorders.J Psychosom Res. 2008 Jun;64(6):567-72. doi: 10.1016/j.jpsychores.2008.02.023. Epub 2008 Apr 28. J Psychosom Res. 2008. PMID: 18501256
-
Post-infection functional gastrointestinal disorders following coronavirus disease-19: a prospective follow-up cohort study.BMC Infect Dis. 2023 Jun 21;23(1):422. doi: 10.1186/s12879-023-08401-x. BMC Infect Dis. 2023. PMID: 37344782 Free PMC article.
-
Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options.J Physiol Pharmacol. 2011 Dec;62(6):591-9. J Physiol Pharmacol. 2011. PMID: 22314561 Review.
Cited by
-
Probiotic treatment induced change of inflammation related metabolites in IBS-D patients/double-blind, randomized, placebo-controlled trial.Food Sci Biotechnol. 2019 Dec 23;29(6):837-844. doi: 10.1007/s10068-019-00717-2. eCollection 2020 Jun. Food Sci Biotechnol. 2019. PMID: 32523793 Free PMC article.
-
Irritable bowel syndrome: a microbiome-gut-brain axis disorder?World J Gastroenterol. 2014 Oct 21;20(39):14105-25. doi: 10.3748/wjg.v20.i39.14105. World J Gastroenterol. 2014. PMID: 25339800 Free PMC article. Review.
-
The Gut-Brain Axis and the Microbiome: Clues to Pathophysiology and Opportunities for Novel Management Strategies in Irritable Bowel Syndrome (IBS).J Clin Med. 2018 Jan 3;7(1):6. doi: 10.3390/jcm7010006. J Clin Med. 2018. PMID: 29301380 Free PMC article. Review.
-
The Influence of the Gut Microbiome on Obesity, Metabolic Syndrome and Gastrointestinal Disease.Clin Transl Gastroenterol. 2015 Jun 18;6(6):e91. doi: 10.1038/ctg.2015.16. Clin Transl Gastroenterol. 2015. PMID: 26087059 Free PMC article.
-
Effect of the standard herbal preparation, STW5, treatment on dysbiosis induced by dextran sodium sulfate in experimental colitis.BMC Complement Med Ther. 2021 Jun 8;21(1):168. doi: 10.1186/s12906-021-03337-8. BMC Complement Med Ther. 2021. PMID: 34103031 Free PMC article.
References
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources