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Review
. 2013 Sep;260(9):2212-9.
doi: 10.1007/s00415-012-6736-7. Epub 2012 Nov 20.

Neurogenic orthostatic hypotension: pathophysiology, evaluation, and management

Manuela Metzler  1 , Susanne Duerr, Roberta Granata, Florian Krismer, David Robertson, Gregor K Wenning
Affiliations
Review

Neurogenic orthostatic hypotension: pathophysiology, evaluation, and management

Manuela Metzler et al. J Neurol. 2013 Sep.

Abstract

Neurogenic orthostatic hypotension is a distinctive and treatable sign of cardiovascular autonomic dysfunction. It is caused by failure of noradrenergic neurotransmission that is associated with a range of primary or secondary autonomic disorders, including pure autonomic failure, Parkinson's disease with autonomic failure, multiple system atrophy as well as diabetic and nondiabetic autonomic neuropathies. Neurogenic orthostatic hypotension is commonly accompanied by autonomic dysregulation involving other organ systems such as the bowel and the bladder. In the present review, we provide an overview of the clinical presentation, pathophysiology, epidemiology, evaluation and management of neurogenic orthostatic hypotension focusing on neurodegenerative disorders.

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Figures

Fig. 1
Fig. 1
Consensus criteria for the diagnosis of MSA. Modified according to [18]. a Diagnostic criteria for the diagnosis of probable MSA. b Diagnostic criteria for the diagnosis of possible MSA. c Additional features suggestive of MSA required for a diagnosis of possible MSA
See this image and copyright information in PMC

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