Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Sep;260(9):2212-9.
doi: 10.1007/s00415-012-6736-7. Epub 2012 Nov 20.

Neurogenic orthostatic hypotension: pathophysiology, evaluation, and management

Manuela Metzler  1 , Susanne Duerr, Roberta Granata, Florian Krismer, David Robertson, Gregor K Wenning
Affiliations
Review

Neurogenic orthostatic hypotension: pathophysiology, evaluation, and management

Manuela Metzler et al. J Neurol. 2013 Sep.

Abstract

Neurogenic orthostatic hypotension is a distinctive and treatable sign of cardiovascular autonomic dysfunction. It is caused by failure of noradrenergic neurotransmission that is associated with a range of primary or secondary autonomic disorders, including pure autonomic failure, Parkinson's disease with autonomic failure, multiple system atrophy as well as diabetic and nondiabetic autonomic neuropathies. Neurogenic orthostatic hypotension is commonly accompanied by autonomic dysregulation involving other organ systems such as the bowel and the bladder. In the present review, we provide an overview of the clinical presentation, pathophysiology, epidemiology, evaluation and management of neurogenic orthostatic hypotension focusing on neurodegenerative disorders.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Consensus criteria for the diagnosis of MSA. Modified according to [18]. a Diagnostic criteria for the diagnosis of probable MSA. b Diagnostic criteria for the diagnosis of possible MSA. c Additional features suggestive of MSA required for a diagnosis of possible MSA
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. (1996) Assessment: clinical autonomic testing report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 46:873–880 - PubMed
    1. (1996) Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. The Consensus Committee of the American Autonomic Society and the American Academy of Neurology. Neurology 46:1470 - PubMed
    1. (1988) Consensus statement: Report and recommendations of the San Antonio conference on diabetic neuropathy. American Diabetes Association American Academy of Neurology. Diabetes care 11:592–597 - PubMed
    1. Allan LM, Ballard CG, Allen J, Murray A, Davidson AW, McKeith IG, Kenny RA. Autonomic dysfunction in dementia. J Neurol Neurosurg Psychiatry. 2007;78:671–677. doi: 10.1136/jnnp.2006.102343. - DOI - PMC - PubMed
    1. Allcock LM, Ullyart K, Kenny RA, Burn DJ. Frequency of orthostatic hypotension in a community based cohort of patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2004;75:1470–1471. doi: 10.1136/jnnp.2003.029413. - DOI - PMC - PubMed

Publication types

MeSH terms