Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Mar 15;132(6):1272-6.
doi: 10.1002/ijc.27965. Epub 2012 Dec 21.

A new approach for elimination of gastric cancer deaths in Japan

Masahiro Asaka  1
Affiliations
Free PMC article

A new approach for elimination of gastric cancer deaths in Japan

Masahiro Asaka. Int J Cancer. .
Free PMC article

Abstract

We explore a strategy for the elimination of gastric cancer deaths in Japan. Most gastric cancer is due to H. pylori infection in Japan. The effect of H. pylori eradication therapy on gastric cancer prevention in younger people is excellent, but it declines along with advancing age. Therefore, a test-and-treat approach to H. pylori infection is recommended in younger people, while for people aged 50 years or older a combination of countermeasures for H. pylori eradication that includes primary prevention and secondary prevention by endoscopic examination will reduce gastric cancer deaths, since this method will increase early detection if the disease occurs. In this paper, I described a new strategy of elimination of gastric cancer deaths in Japan due to such a high quality of diagnosis and treatment for gastric cancer. If this strategy succeeds, the incidence of gastric cancer in Japan may decrease much longer than 10 years.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Progress of H. pylori infection. H. pylori-related chronic gastritis is leading to peptic ulcer, gastric MALT lymphoma, functional dyspepsia, gastric polyps, ITP, atrophic gastritis and gastric cancer.
Figure 2
Figure 2
Possible rate of gastric cancer prevention by eradication of Helicobacter pylori.
Figure 3
Figure 3
An approach for elimination of gastric cancer deaths in younger generation (before 20 years) in Japan.
Figure 4
Figure 4
An approach for elimination of gastric cancer deaths after 50 years in Japan.
See this image and copyright information in PMC

References

    1. Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127:2893–917. - PubMed
    1. Warren JR, Marshall BJ. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983;1:1273–5. - PubMed
    1. International Agency for Research on Cancer, World Health Organization. Schistosomes, liver flukes and Helicobacter pylori. IARC Monogr Eval Carcinog Risk Hum. 1994;61:177–241. - PMC - PubMed
    1. Fukase K, Kato M, Kikuchi S, et al. Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial. Lancet. 2008;372:392–7. - PubMed
    1. Hisamichi S, Sugawara N. Mass screening for gastric cancer by X-ray examination. Jpn J Clin Oncol. 1984;11:211–33. - PubMed

MeSH terms