Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2012 Apr;4(2):83-5.
doi: 10.4103/0974-7753.96910.

Silvery grey hair: clue to diagnose immunodeficiency

Ms Sahana  1 , S Sacchidanand, R Hiremagalore, Gs Asha
Affiliations
Case Reports

Silvery grey hair: clue to diagnose immunodeficiency

Ms Sahana et al. Int J Trichology. 2012 Apr.

Abstract

Silvery hair is a common presentation of rare group of autosomal recessive disorders called Silvery hair syndromes including Griscelli syndrome (GS), Chediak-Higashi syndrome, and Elejalde syndrome. GS is characterized by a silvery grey sheen to hair, large clumped melanosomes in hair shaft, partial albinism, and variable cellular immunodeficiency. We report two cases of GS with classical clinical features and confirmatory findings by microscopic skin and hair examination.

Keywords: Griscelli syndrome; immunodeficiency; silvery hair.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Eight-year-old boy with silvery grey hair
Figure 2
Figure 2
Hair shaft showing irregular pigment clumps
Figure 3
Figure 3
Silvery grey hair with hypopigmented macule on the face
See this image and copyright information in PMC

References

    1. Mancini AJ, Chan LS, Paller AS. Partial albinism with immunodeficiency: Griscelli syndrome: Report of a case and review of literature. J Am Acad Dermatol. 1998;38:295–300. - PubMed
    1. Griscelli C, Prunieras M. Pigment dilution and immunodeficiency: A new syndrome. Int J Dermatol. 1978;17:788–91. - PubMed
    1. Sheela SR, Latha M, Injody SJ. Griscelli syndrome: Rab27a mutation. Indian Pediatr. 2004;41:944–7. - PubMed
    1. Manglani M, Adhvaryu K, Seth B. Griscelli syndrome - a case report. Indian Pediatr. 2004;41:734–7. - PubMed
    1. Fukuda M. Versatile role of Rab27 in membrane trafficking: focus on the Rab27 effector families. J Biochem. 2005;137:9–16. - PubMed

Publication types