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. 2012 Jul;7(3):171-9.

Synthesis and antioxidant evaluation of some novel ortho-hydroxypyridine-4-one iron chelators

M Mohammadpour  1 , A Sadeghi, A Fassihi, L Saghaei, A Movahedian, M Rostami
Affiliations

Synthesis and antioxidant evaluation of some novel ortho-hydroxypyridine-4-one iron chelators

M Mohammadpour et al. Res Pharm Sci. 2012 Jul.

Abstract

A series of ortho-hydroxypyridine-4-ones were prepared in high yields and evaluated for antioxidant and iron chelating activities. N(1)-H hydroxypyridinones Va, Vb, and Ve were the best radical scavengers in DPPH free radical scavenging assay. Compound Vb was proved to be the most potent compound in hydrogen peroxide scavenging assay. All of the synthesized compounds had very close chelating ability, compounds containing N(1)-CH3 hydroxypyridinone ring were stronger chelating agents.

Keywords: Antioxidant activity; Iron chelating activity; Ortho-Hydroxypyridine-4-one; Radical scavenging activity.

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Figures

Fig. 1
Fig. 1
CP20 and CP08: Two well-known 3-hydroxy pyridin-4-one derivatives
Scheme 1
Scheme 1
General procedure for the synthesis of the studied compounds
Fig. 2
Fig. 2
The observed tautomerism in compounds IVa-c
Fig. 3
Fig. 3
% DPPH scavenging activity of the compounds Va-f (0.00625-0.4 mg/ml)
Fig. 4
Fig. 4
DPPH reaction with an antioxidant
See this image and copyright information in PMC

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