[An evaluation of the toxic and antitumor action of farmorubicin administered to H-strain mice with Ehrlich ascitic cancer]

Abstract

The toxic and antitumour action of farmorubicin was investigated in experiments on mice. Data on the high antitumor activity were obtained after single application of the drug and at 5-day treatment of mice bearing the Ehrlich ascites tumour. It has been established that farmorubicin used in the tolerant dose was comparatively nontoxic--nonmyelotoxic. At higher doses the toxic damages manifested in different periods and depended on the employed doses. A decrease in the heart weight has permitted revealing the formorubicin-induced cardiotoxicity which was confirmed (after 5 injections of the preparation in a dose of LD 50) by electron microscopy.