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Meta-Analysis
. 2012 Nov 26;31(1):98.
doi: 10.1186/1756-9966-31-98.

Prognostic significance of Cdx2 immunohistochemical expression in gastric cancer: a meta-analysis of published literatures

Xiao-Tong Wang  1 , Wei-Yuan Wei, Fan-Biao Kong, Chao Lian, Wen Luo, Qiang Xiao, Yu-Bo Xie
Affiliations
Meta-Analysis

Prognostic significance of Cdx2 immunohistochemical expression in gastric cancer: a meta-analysis of published literatures

Xiao-Tong Wang et al. J Exp Clin Cancer Res. .

Abstract

Cdx2 is a homeobox domain-containing transcription factor that is important in the development and differentiation of the intestinal cells, and served as a potential biomarker of tumor progression in early intestinal-type gastric cancer. However, its prognostic value and significance in gastric cancer remain controversial. A meta-analysis based on published studies was performed to obtain an accurate evaluation of the association between the presence of Cdx2-positive in clinical samples and clinical outcome. A total of 13 eligible retrospective cohort studies with 1513 patients were included. Cdx2-positive cases were significantly associated with higher male-to-female ratio (RR=1.27, 95% CI: 1.17-1.38, P<0.00001 fixed-effect), lower (I+II) clinical stage (RR=1.63, 95% CI: 1.42-1.87, P<0.00001 fixed-effect), better histologic differentiation (RR=1.54, 95% CI: 1.34-1.76, P<0.00001 fixed-effect), and lower rate of vascular invasion (RR=1.23, 95% CI: 1.08-1.41, P=0.002 fixed-effect) and lymph node metastasis (RR=1.52, 95% CI: 1.33-1.73, P<0.00001 fixed-effect), as well as higher 5-year survival rate (HR=2.22, 95% CI: 1.78-2.75, P<0.00001 fixed-effect). However, the presence of Cdx2 was not associated with tumor size. In summary, Cdx2 is a prognostic factor in gastric cancer, which acts as a marker of good outcome in patients with gastric cancer. Further clinical studies are needed to confirm the role of Cdx2 in clinical practice.

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Figures

Figure 1
Figure 1
Flow chart for our meta-analysis.
Figure 2
Figure 2
Forest plot of RR was assessed for association between Cdx2 and clinical pathologic features, such as sex (A), tumor size (B), clinical stage (C), differentiation (D), vascular invasion (E), and lymph node metastasis (F).
Figure 3
Figure 3
Forest plot of HR for 5-year survival rate among included studies. It shows the combined HR which is calculated by a fixed-effects mode, and it demonstrates that Cdx2 can work as prognostic factors on 5-year survival rate in gastric cancer patients.
Figure 4
Figure 4
Funnel plot of studies of Cdx2 positivity in gastric cancer.
See this image and copyright information in PMC

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References

    1. Sun P, Xiang JB, Chen ZY. Meta-analysis of adjuvant chemotherapy after radical surgery for advanced gastric cancer. Br J Surg. 2009;96:26–33. doi: 10.1002/bjs.6408. - DOI - PubMed
    1. Hirasawa T, Gotoda T, Miyata S, Kato Y, Shimoda T. Incidence of lymph node metastasis and the feasibility of endoscopic resection for undifferentiated-type early gastric cancer. Gastric Cancer. 2009;12:148–52. doi: 10.1007/s10120-009-0515-x. - DOI - PubMed
    1. Park do Y, Srivastava A, Kim GH, Mino-Kenudson M, Deshpande V. CDX2 expression in the intestinal-type gastric epithelial neoplasia: frequency and significance. Mod Pathol. 2010;23:54–61. doi: 10.1038/modpathol.2009.135. - DOI - PubMed
    1. Xie Y, Li L, Wang X, Qin Y, Qian Q. Overexpression of Cdx2 inhibits progression of gastric cancer in vitro. Int J Oncol. 2010;36:509–16. - PubMed
    1. Kim HS, Lee JS, Freund JN, Min KW, Lee JS. CDX-2 homeobox gene expression in human gastric carcinoma and precursor lesions. J Gastroenterol Hepatol. 2006;21:438–42. doi: 10.1111/j.1440-1746.2005.03933.x. - DOI - PubMed

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