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. 2012 Nov 26;12(1):50.
doi: 10.1186/1475-2867-12-50.

Algae extracts and methyl jasmonate anti-cancer activities in prostate cancer: choreographers of 'the dance macabre'

Ammad Ahmad Farooqi  1 , Ghazala Butt, Zubia Razzaq
Affiliations

Algae extracts and methyl jasmonate anti-cancer activities in prostate cancer: choreographers of 'the dance macabre'

Ammad Ahmad Farooqi et al. Cancer Cell Int. .

Abstract

There is an overwhelmingly increasing trend of analysis of naturally occurring ingredients in treatment of prostate cancer. Substantial fraction of information has been added that highlights activity at various levels and steps of deregulated cellular proliferation, metastasis and apoptosis. Among such ingredients, algae extracts and jasmonates are documented to have anti-cancer activity in vitro and in vivo and induce growth inhibition in cancer cells, while leaving the non-transformed cells intact. In this short review we outline systematically, how these ingredients predispose prostate cancer cells to undergo apoptosis.

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Figures

Figure 1
Figure 1
Showing TRAIL mediated apoptosis. There is an overexpression of antiapoptotic proteins that impairs the cell death. Jasmonates induce apoptosis via multistep activity.
See this image and copyright information in PMC

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