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Review
. 2013 Jul;48(7):781-97.
doi: 10.1007/s00535-012-0712-y. Epub 2012 Nov 27.

Cancer stem cells: the 'heartbeat' of gastric cancer

Guihua Xu  1 , Jie Shen, Xiaohui Ou Yang, Masakiyo Sasahara, Xiulan Su
Affiliations
Review

Cancer stem cells: the 'heartbeat' of gastric cancer

Guihua Xu et al. J Gastroenterol. 2013 Jul.

Abstract

Gastric cancer (GC) remains one of the most common cancers worldwide. Its prevalence is still on the rise in the developing countries due to the ageing population. The cancer stem cell (CSC) theory provides a new insight into the interpretation of tumor initiation, aggressive growth, recurrence, and metastasis of cancer, as well as the development of new strategies for cancer treatment. This review will focus on the progress of biomarkers and signaling pathways of CSCs, the complex crosstalk networks between the microenvironment and CSCs, and the development of therapeutic approaches against CSCs, predominantly focusing on GC.

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