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. 2012 Nov;67(11):1299-302.
doi: 10.6061/clinics/2012(11)13.

Relationship between plasminogen activator inhibitor type-1 (PAI-1) gene polymorphisms and osteoporosis in Turkish women

Merih Ozgen  1 , Didem Turgut Cosan, Fulya Doganer, Ahu Soyocak, Onur Armagan, Hasan Veysi Gunes, Irfan Degirmenci, Gulsah Ogutler Ozkara, Fezan Sahin Mutlu
Affiliations

Relationship between plasminogen activator inhibitor type-1 (PAI-1) gene polymorphisms and osteoporosis in Turkish women

Merih Ozgen et al. Clinics (Sao Paulo). 2012 Nov.

Abstract

Objective: The development of osteoporosis is associated with several risk factors, such as genetic structures that affect bone turnover and bone mass. The impact of genetic structures on osteoporosis is not known. Plasminogen activator inhibitor type-1 regulates the bone matrix and bone balance. This study assessed the correlation between plasminogen activator inhibitor type-1 gene 4G/5G polymorphisms and osteoporosis in a population of Turkish women.

Methods: A total of 195 postmenopausal female patients who were diagnosed with osteoporosis (Group I) based on bone mineral density measurements via dual-energy x-ray absorptiometry and 90 females with no osteoporosis (Group II) were included in this study. Correlations between PAI-1 gene 4G/5G polymorphisms and osteoporosis were investigated through the identification of PAI-1 gene 4G/5G polymorphism genotypes using the polymerase chain reaction.

Results: No significant differences in the genotype and allele frequency of 4G/5G plasminogen activator inhibitor type-1 polymorphisms were observed between the two groups, and both groups exhibited the most frequently observed 4G5G genotype.

Conclusion: No correlation between the development of osteoporosis in the female Turkish population and 4G/5G plasminogen activator inhibitor type-1 gene polymorphisms was observed.

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Conflict of interest statement

No potential conflict of interest was reported.

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References

    1. Kanis JA, Melton LJ, Christiansen C, Johnston CC, Khaltaev N. The diagnosis of osteoporosis. J Bone Miner Res. 1994;9(8):1137–41. - PubMed
    1. Dontas IA, Yiannakopoulos CK. Risk factors and prevention of osteoporosis-related fractures. Journal of Musculoskeletal & Neuronal Interactions. 2007;7(3):268–72. - PubMed
    1. Borer KT. Physical activity in the prevention and amelioration of osteoporosis in women: interaction of mechanical, hormonal and dietary factor. Sports Medicine. 2005;35(9):779–830. - PubMed
    1. Eisman JA. Genetics of osteoporosis. Endocr Rev. 1999;20(6):788–804. - PubMed
    1. Ralston SH. Genetic Control of Susceptibility to Osteoporosis. The Journal of Clinical Endocrinology & Metabolism. 2002;87(6):2460–6. - PubMed

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