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. 2012 Mar;1(2):183-8.
doi: 10.1002/adhm.201100024. Epub 2012 Feb 29.

Enhanced enzymatic thermal stability and activity in functionalized mesoporous silica monitored by (31) p NMR

Kheireddine El-Boubbou  1 , David A Schofield, Christopher C Landry
Affiliations

Enhanced enzymatic thermal stability and activity in functionalized mesoporous silica monitored by (31) p NMR

Kheireddine El-Boubbou et al. Adv Healthc Mater. 2012 Mar.

Abstract

Organophosphorus hydrolase (OPH) is immobilized on ammonium-modified mesoporous silica particles. Thermal stability and activity are measured with a (31) P NMR assay of the conversion of paraoxon (toxic) to its non-toxic hydrolysis product. After immobilization, OPH is significantly more active at room temperature and retained activity even after being heated to 45 °C for 1 month.

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