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. 2012 May;1(3):316-20.
doi: 10.1002/adhm.201100033. Epub 2012 Apr 2.

Cascaded photoinduced drug delivery to cells from multifunctional core-shell mesoporous silica

Axel Schlossbauer  1 , Anna M Sauer, Valentina Cauda, Alexandra Schmidt, Hanna Engelke, Ulrich Rothbauer, Kourosh Zolghadr, Heinrich Leonhardt, Christoph Bräuchle, Thomas Bein
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Cascaded photoinduced drug delivery to cells from multifunctional core-shell mesoporous silica

Axel Schlossbauer et al. Adv Healthc Mater. 2012 May.

Abstract

Different bioactive molecules are released into living cells from lipid-covered mesoporous silica nanoparticles. The release is triggered by light, as the particles feature covalently attached photosensitizers as membrane-opening agents. It is demonstrated that the particles achieve endosomal escape and that they release their cargo into the cytosol.

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