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Review
. 2013 Mar 5;185(4):309-16.
doi: 10.1503/cmaj.120951. Epub 2012 Nov 26.

Grapefruit-medication interactions: forbidden fruit or avoidable consequences?

David G Bailey  1 , George Dresser, J Malcolm O Arnold
Affiliations
Review

Grapefruit-medication interactions: forbidden fruit or avoidable consequences?

David G Bailey et al. CMAJ. .
No abstract available

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Figures

Figure 1:
Figure 1:
Sequential first-pass elimination of a drug, such as felodipine, through metabolism in enterocytes of the small intestine, then hepatocytes of the liver. The percentages of the initial dose that are available before and after passage through the gut wall and liver are shown. Although felodipine is 100% absorbed from the gastrointestinal tract, its bioavailability is only 15% after oral administration. CYP3A4 = cytochrome P450 enzyme 3A4.
See this image and copyright information in PMC

Comment in

  • Grapefruit-medication interactions.
    Greenblatt DJ, Derendorf H. Greenblatt DJ, et al. CMAJ. 2013 Apr 2;185(6):507. doi: 10.1503/cmaj.113-2109. CMAJ. 2013. PMID: 23550054 Free PMC article. No abstract available.
  • Grapefruit-medication interactions.
    Bailey DG. Bailey DG. CMAJ. 2013 Apr 2;185(6):507-8. doi: 10.1503/cmaj.113-2110. CMAJ. 2013. PMID: 23550055 Free PMC article. No abstract available.
  • Grapefruit juice and clopidogrel.
    Friesen MH. Friesen MH. CMAJ. 2013 Sep 3;185(12):1066. doi: 10.1503/cmaj.113-2126. CMAJ. 2013. PMID: 24003187 Free PMC article. No abstract available.
  • Grapefruit juice and clopidogrel.
    Bailey DG. Bailey DG. CMAJ. 2013 Sep 3;185(12):1066. doi: 10.1503/cmaj.113-2127. CMAJ. 2013. PMID: 24003188 Free PMC article. No abstract available.

References

    1. Bailey DG, Spence JD, Edgar B, et al. Ethanol enhances the hemodynamic effects of felodipine. Clin Invest Med 1989;12:357–62 - PubMed
    1. Bailey DG, Arnold JMO, Spence JD. Grapefruit juice–drug interactions. Br J Clin Pharmacol 1998;46:101–10 - PMC - PubMed
    1. Bailey DG, Spence JD, Munoz C, et al. Interaction of citrus juices with felodipine and nifedipine. Lancet 1991;337:268–9 - PubMed
    1. Bailey DG. Fruit juice inhibition of uptake transport: a new type of food–drug interaction. Br J Clin Pharmacol 2010;70:645–55 - PMC - PubMed
    1. Wilkinson GR. Drug metabolism and variability among patients in drug response. N Engl J Med 2005;352:2211–21 - PubMed

MeSH terms