Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Nov 27;109(48):19519-20.
doi: 10.1073/pnas.1217267109. Epub 2012 Nov 26.

Yin and yang of mediator function revealed by human mutants

Arnold J Berk  1
Affiliations
Comment

Yin and yang of mediator function revealed by human mutants

Arnold J Berk. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Diagram representing simultaneous binding of several regulatory TF activation domains to different surfaces of the Mediator. dsDNA is represented by a thin blue line and histone octamers by orange discs. Regulatory TFs bind to specific DNA sequences at promoter proximal regions (bottom left of Mediator) and distal enhancers (top of Mediator) via their DNA-binding domains (blue), which are linked through flexible regions of polypeptide to activation domains (green). In response to interactions with activation domains, Mediator binds to RNA Pol II and promotes binding of the polymerase and its general TFs to the TSS. [Reprinted with permission from W. H. Freeman and Company (21).]
See this image and copyright information in PMC

Comment on

References

    1. Kornberg RD. Mediator and the mechanism of transcriptional activation. Trends Biochem Sci. 2005;30(5):235–239. - PubMed
    1. Conaway RC, Conaway JW. Function and regulation of the Mediator complex. Curr Opin Genet Dev. 2011;21(2):225–230. - PMC - PubMed
    1. Malik S, Roeder RG. The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet. 2010;11(11):761–772. - PMC - PubMed
    1. Larivière L, Seizl M, Cramer P. A structural perspective on Mediator function. Curr Opin Cell Biol. 2012;24(3):305–313. - PubMed
    1. Lee TI, Young RA. Transcription of eukaryotic protein-coding genes. Annu Rev Genet. 2000;34:77–137. - PubMed

MeSH terms