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Comment
. 2012 Dec;122(12):4339-41.
doi: 10.1172/JCI66724. Epub 2012 Nov 26.

Understanding the TXA seizure connection

Debra A Schwinn  1 , G Burkhard Mackensen, Emery N Brown
Affiliations
Comment

Understanding the TXA seizure connection

Debra A Schwinn et al. J Clin Invest. 2012 Dec.

Abstract

Transexamic acid (TXA) is an antifibrinolytic that has been used successfully to prevent blood loss during major surgery. However, as its usage has increased, there have been growing reports of postsurgical seizure events in cardiac surgery patients. In this issue of the JCI, Lecker et al. explore this connection and suggest that TXA-mediated inhibition of glycine receptors may underlie the effect. This finding prompted the authors to explore the preclinical efficacy of common anesthetics that function by reducing the TXA-mediated inhibition to prevent or modify postsurgical seizures.

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References

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