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. 2012 Nov 27;17(12):14058-66.
doi: 10.3390/molecules171214058.

Norcembranoidal diterpenes from a Formosan soft coral Sinularia sp

Wei-Hsuan Yen  1 , Li-Chung Hu, Jui-Hsin Su, Mei-Chin Lu, Wen-Hung Twan, Show-Ying Yang, Yung-Chi Kuo, Ching-Feng Weng, Chia-Hung Lee, Yueh-Hsiung Kuo, Ping-Jyun Sung
Affiliations

Norcembranoidal diterpenes from a Formosan soft coral Sinularia sp

Wei-Hsuan Yen et al. Molecules. .

Abstract

Two norcembranoidal diterpenes, 5-episinuleptolide acetate (1) and scabrolide D (2), were isolated from a Formosan octocoral identified as Sinularia sp. The structures of norcembranoids 1 and 2 were established by spectroscopic methods and by comparison of the spectral data with those of known analogues and 1 was proven to be a new natural product. Norcembranoid 1 was found to exhibit cytotoxicity toward a panel of tumor cells.

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Figures

Figure 1
Figure 1
The soft coral Sinularia sp. and the structures of 5-episinuleptolide acetate (1) and scabrolide D (2).
Figure 2
Figure 2
The 1H–1H COSY and key HMBC (protons→quaternary carbons) correlations for 1.
Figure 3
Figure 3
The computer-generated model of 1 using MM2 force field calculations and the calculated distances (Å) between selected protons with key NOESY correlations.
See this image and copyright information in PMC

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