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Case Reports
. 2012 Nov 27:2012:bcr2012007221.
doi: 10.1136/bcr-2012-007221.

A unique presentation of four thrombotic events at a time

Affiliations
Case Reports

A unique presentation of four thrombotic events at a time

Ali Raza Rajani et al. BMJ Case Rep. .

Abstract

A 72-year-old man was referred to our hospital as a case of postcardiac arrest following a long distance air flight. Work-up in the emergency department revealed the presence of deep vein thrombosis (DVT), bilateral pulmonary embolism, inferior STEMI (ST elevation myocardial infarction) and ischaemic stroke. He received thrombolysis by recombinant tissue plasminogen activator (tPA) following which his haemodynamic status improved, but he developed haemorrhagic transformation of the stroke as a complication. The haemorrhagic lesion gradually resolved with conservative management, leaving behind a residual neurological deficit. His haemodynamic status was stable after the management. Although a diagnosis of right-to-left shunt lesion was highly suggestive in this condition, it could not be confirmed on the transthoracic echocardiogram. Our patient had a unique presentation of multiple thrombi in different organs that caused significant morbidity and haemodynamic instability. There are no well-established guidelines that discuss the acute management of such cases. This situation requires a careful assessment and management of the patient by a multidisciplinary team.

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Figures

Figure 1
Figure 1
ECG at admission showing sinus rhythm with ST elevation in inferior leads.
Figure 2
Figure 2
CT pulmonary angiogram showing bilateral pulmonary embolism.
Figure 3
Figure 3
Brain CT showing large right hemispheric hypodense area with patchy area of bleeding seen at the temporal lobe with associated mass effect but no significant midline shift.
Figure 4
Figure 4
Follow-up brain CT showing resolving haemorrhagic infarction.

References

    1. Jaff MR, McMurtry MS, Archer SL, et al. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation 2011;123:1788–1830. - PubMed
    1. Hagen PT, Scholz DG, Edwards WD. Incidence and size of patent foramen ovale during the first 10 decades of life: an autopsy study of 965 normal hearts. Mayo Clin Proc 1984;59:17–20. - PubMed
    1. Liu YF, Bayliss M. Paradoxical embolism: a rare complication of thrombolysis. Emerg Med J 2008;25:180–1. - PubMed
    1. Madani H, Ransom PA. Paradoxical embolus illustrating speed of action of recombinant tissue plasminogen activator in massive pulmonary embolism. Emerg Med J 2007;24:441. - PMC - PubMed
    1. Dao CN, Tobis JM. PFO and paradoxical embolism producing events other than stroke. Catheter Cardiovasc Interv 2011;77:903–9. - PubMed

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