Malaria and the heart
- PMID: 23188857
- PMCID: PMC4544263
- DOI: 10.1136/bcr-2012-007275
Malaria and the heart
Abstract
A 40-year-old healthy manual labourer from a malaria endemic area with no known risk factors for atherosclerotic coronary vascular disease was admitted to our hospital with a history of fever with chills and rigours. Physical examination revealed tachypnoea and icterus. Peripheral smear showed trophozoites of Plasmodium vivax and thrombocytopaenia. The patient was administered artesunate. Six hours after admission, he complained of severe substernal chest pain. A 12-lead ECG revealed ST elevations in leads I, II and aVL. Troponin T and creatine kinase MB were elevated and the random blood sugar was 49 mg%. Echocardiogram revealed left ventricle lateral wall hypokinesia. Hypoglycaemia was corrected. A provisional diagnosis of acute coronary syndrome as a complication of malaria or its treatment was made. He was treated with low molecular weight heparin and nitrates. The patient improved symptomatically. A repeat ECG was normal.
Figures






Similar articles
-
Congenital Plasmodium vivax in a 3-day-old neonate: a case report.J Med Case Rep. 2024 Nov 22;18(1):558. doi: 10.1186/s13256-024-04879-4. J Med Case Rep. 2024. PMID: 39574171 Free PMC article.
-
Diuretic effect of sodium artesunate in patients with malaria.Am J Trop Med Hyg. 2002 Nov;67(5):473-4. doi: 10.4269/ajtmh.2002.67.473. Am J Trop Med Hyg. 2002. PMID: 12479546
-
Oral artesunate for neonatal malaria.J Trop Pediatr. 2010 Dec;56(6):452-3. doi: 10.1093/tropej/fmq007. Epub 2010 Feb 8. J Trop Pediatr. 2010. PMID: 20144934
-
Artesunate: investigational drug for the treatment of severe falciparum malaria in Hawai'i.Hawaii Med J. 2011 Apr;70(4):77-9. Hawaii Med J. 2011. PMID: 21785506 Free PMC article. Review.
-
Acute acalculous cholecystitis complicating an imported case of mixed malaria caused by Plasmodium falciparum and Plasmodium vivax.Int J Infect Dis. 2010 Sep;14 Suppl 3:e217-9. doi: 10.1016/j.ijid.2009.07.018. Epub 2009 Nov 20. Int J Infect Dis. 2010. PMID: 19932042 Review.
Cited by
-
Malaria and vascular endothelium.Arq Bras Cardiol. 2014 Aug;103(2):165-9. doi: 10.5935/abc.20140088. Epub 2014 Jul 9. Arq Bras Cardiol. 2014. PMID: 25014058 Free PMC article. Review.
-
Heart failure associated with imported malaria: a nationwide Danish cohort study.ESC Heart Fail. 2021 Oct;8(5):3521-3529. doi: 10.1002/ehf2.13441. Epub 2021 Jul 27. ESC Heart Fail. 2021. PMID: 34313024 Free PMC article.
-
Cardiovascular Findings in Severe Malaria: A Review.Glob Heart. 2020 Nov 4;15(1):75. doi: 10.5334/gh.789. Glob Heart. 2020. PMID: 33299771 Free PMC article.
-
The effect of malaria and anti-malarial drugs on skeletal and cardiac muscles.Malar J. 2016 Nov 2;15(1):524. doi: 10.1186/s12936-016-1577-y. Malar J. 2016. PMID: 27806725 Free PMC article. Review.
References
-
- White NJ, Breman JG. Malaria. In: Fauci, Kasper, Hauser, Jameson, Loscalzo Longo Harrison's principles of internal medicine. New York, USA: McGraw Hill, 2012.
-
- Kochar DK. Severe Plasmodium vivax malaria: a report on serial cases from Bikaner in northwestern India. Am J Trop Med Hyg 2009;80:194–8. - PubMed
-
- Franzen D, Curtius JM, Heitz W, et al. Cardiac involvement during and after malaria. Clin Invest 1992;70:670–3. - PubMed
-
- Bethell DB, Phuong PT, Phuong CX, et al. Electrocardiographic monitoring in severe falciparum malaria. Trans R Soc Trop Med Hyg 1996;90:266–9. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous